Detailed information of TA system TA032639

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2213837..2214507
• Replicon: chromosome
• Accession: NZ_AP019373
• Organism: Sulfuricystis thermophila strain M52

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: M52SOB_RS11145
• Protein ID: WP_131111875.1
• Coordinates: 2213837..2214268 (-)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: M52SOB_RS11150
• Protein ID: WP_131111876.1
• Coordinates: 2214268..2214507 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M52SOB_RS11115	2209521..2210915	-	1395	WP_131111870.1	oligosaccharide flippase family protein	-
M52SOB_RS11120	2210928..2211566	-	639	WP_131111871.1	adenylyl-sulfate kinase	-
M52SOB_RS11125	2211929..2212036	-	108	Protein_2192	NAD-dependent epimerase/dehydratase family protein	-
M52SOB_RS11130	2212226..2212774	-	549	WP_131111872.1	dTDP-4-dehydrorhamnose 3,5-epimerase	-
M52SOB_RS11135	2212859..2213293	-	435	WP_131111873.1	type II toxin-antitoxin system VapC family toxin	-
M52SOB_RS11140	2213290..2213580	-	291	WP_131111874.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
M52SOB_RS11145	2213837..2214268	-	432	WP_131111875.1	PIN domain-containing protein	Toxin
M52SOB_RS11150	2214268..2214507	-	240	WP_131111876.1	DUF6364 family protein	Antitoxin
M52SOB_RS11155	2214622..2215518	-	897	WP_131111877.1	glucose-1-phosphate thymidylyltransferase RfbA	-
M52SOB_RS11160	2215545..2216678	-	1134	WP_172601824.1	AAA family ATPase	-
M52SOB_RS11165	2216737..2217639	-	903	WP_131111878.1	dTDP-4-dehydrorhamnose reductase	-
M52SOB_RS11170	2217641..2218702	-	1062	WP_131111879.1	dTDP-glucose 4,6-dehydratase	-
M52SOB_RS11175	2218699..2219052	-	354	WP_131111880.1	H-NS histone family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-131)

Antitoxin

• Protein of unknown function DUF6364 (4-42)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15787.25 Da
• Isoelectric Point: 7.4359

>T32639 WP_131111875.1 NZ_AP019373:c2214268-2213837 [Sulfuricystis thermophila]
MRALLDVNVLIALLDANHLQHRRATEWLEENAASGWASCPLTQNGCIRIMSHPSYPNPVPASAVAERLQEAVAHPLHQFW
PDDISMLTPGVIDWRRILGSRQVTDAYLLALAVKHKGRLVTLDKGIPRLAVKGTSDSSLELIV

Nucleotide

• Length: 432 bp

>T32639 NZ_AP019373:c2214268-2213837 [Sulfuricystis thermophila]
ATGCGGGCTTTGCTGGATGTGAATGTGCTGATCGCGTTGCTGGACGCCAACCATCTACAGCATCGCCGTGCGACAGAGTG
GCTGGAAGAAAATGCTGCGTCAGGATGGGCCTCCTGTCCTCTTACCCAGAATGGATGCATACGCATCATGTCCCACCCGA
GCTATCCGAATCCTGTTCCTGCGAGCGCAGTCGCCGAAAGGCTGCAAGAGGCGGTCGCCCACCCTCTGCACCAGTTTTGG
CCAGACGACATCAGCATGCTGACTCCCGGCGTGATTGACTGGAGGCGCATTCTCGGCTCCCGCCAAGTGACGGATGCCTA
TTTGCTCGCATTGGCGGTGAAGCACAAAGGCCGCCTGGTGACGCTCGACAAGGGCATCCCGCGCCTTGCCGTGAAGGGAA
CGAGCGATTCCAGCCTAGAGTTGATCGTTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8429.44 Da
• Isoelectric Point: 7.0104

>AT32639 WP_131111876.1 NZ_AP019373:c2214507-2214268 [Sulfuricystis thermophila]
MRTTLDIDEDVLNAAKALARQQHQSAGQVVSQLLRDALTGRANRLAEGGKAVVGFRPFASGANIVTNDQVNALREQEGV

Nucleotide

• Length: 240 bp

>AT32639 NZ_AP019373:c2214507-2214268 [Sulfuricystis thermophila]
ATGAGGACGACGCTGGATATCGACGAAGACGTATTGAACGCCGCCAAGGCATTGGCAAGGCAGCAGCATCAATCTGCCGG
CCAAGTCGTTTCGCAGCTTCTGCGGGATGCATTGACGGGTCGGGCGAACCGATTGGCGGAAGGTGGTAAGGCCGTGGTAG
GGTTTCGGCCATTCGCAAGTGGCGCAAACATCGTTACCAACGATCAAGTCAATGCCTTGCGCGAGCAGGAAGGTGTTTGA