32638

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2131135..2131736 Replicon chromosome
Accession NZ_AP019373
Organism Sulfuricystis thermophila strain M52

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag M52SOB_RS10750 Protein ID WP_131111805.1
Coordinates 2131135..2131431 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag M52SOB_RS10755 Protein ID WP_131111806.1
Coordinates 2131437..2131736 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M52SOB_RS10730 2126450..2127181 + 732 WP_131111801.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
M52SOB_RS10735 2127441..2128964 + 1524 WP_131111802.1 polyphosphate:AMP phosphotransferase -
M52SOB_RS10740 2128961..2130301 + 1341 WP_131111803.1 amino-acid N-acetyltransferase -
M52SOB_RS10745 2130337..2130609 + 273 WP_131111804.1 oxidative damage protection protein -
M52SOB_RS10750 2131135..2131431 + 297 WP_131111805.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M52SOB_RS10755 2131437..2131736 + 300 WP_131111806.1 putative addiction module antidote protein Antitoxin
M52SOB_RS10760 2131779..2132450 - 672 WP_131112521.1 ribose-5-phosphate isomerase RpiA -
M52SOB_RS10765 2132569..2133141 + 573 WP_131111807.1 hypothetical protein -
M52SOB_RS10770 2133196..2133597 - 402 WP_172601818.1 PIN domain-containing protein -
M52SOB_RS10775 2133603..2133818 - 216 WP_131111809.1 hypothetical protein -
M52SOB_RS10780 2133933..2135372 - 1440 WP_284155081.1 dihydrolipoyl dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(50-92)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11021.74 Da        Isoelectric Point: 10.2160

>T32638 WP_131111805.1 NZ_AP019373:2131135-2131431 [Sulfuricystis thermophila]
MIEIRKTDLFAEWLDGLRDIQGRARIQARIERLAAGNPGDVEPVGEGVSELRIDYGPGYRVYFKQRGRKLIILLAGGDKS
TQAKDIKTALRIARNLLE

Download         Length: 297 bp

>T32638 NZ_AP019373:2131135-2131431 [Sulfuricystis thermophila]
ATGATCGAGATTCGGAAGACCGACCTATTTGCCGAGTGGCTCGATGGACTTCGTGATATCCAGGGGAGGGCCCGAATCCA
GGCCAGGATCGAAAGGCTTGCGGCCGGGAATCCTGGCGATGTCGAGCCCGTTGGCGAAGGCGTTTCAGAATTACGTATCG
ACTACGGACCGGGCTACCGGGTGTATTTCAAGCAGCGCGGACGCAAGCTGATCATTTTGTTGGCAGGCGGTGACAAGAGC
ACTCAGGCCAAGGACATCAAAACAGCTTTGCGTATCGCCAGAAACCTTTTGGAGTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10561.07 Da        Isoelectric Point: 6.2230

>AT32638 WP_131111806.1 NZ_AP019373:2131437-2131736 [Sulfuricystis thermophila]
MAKIVTTRYDVAEHLRTPEEMAAYLEACLEEANGDAAFIAKALGDIARAKGMAQVARDAGLSRESLYKALSGERSPSFDT
ILKVISALGLKLHAEASHG

Download         Length: 300 bp

>AT32638 NZ_AP019373:2131437-2131736 [Sulfuricystis thermophila]
ATGGCAAAGATCGTCACCACTCGCTACGACGTTGCAGAACACCTCAGAACGCCTGAAGAAATGGCCGCCTATCTCGAAGC
CTGCCTAGAAGAAGCGAACGGAGATGCGGCCTTTATCGCCAAGGCGCTCGGCGACATCGCTCGCGCAAAAGGAATGGCAC
AGGTTGCCCGCGACGCGGGTCTTTCCCGCGAAAGTCTCTATAAGGCGCTTTCGGGCGAACGTAGCCCGAGCTTCGACACG
ATCCTCAAGGTGATCAGCGCCTTGGGATTGAAATTGCATGCCGAAGCCAGTCACGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References