Detailed information of TA system TA032637

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 1940230..1941752
• Replicon: chromosome
• Accession: NZ_AP019373
• Organism: Sulfuricystis thermophila strain M52

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: -
• Locus tag: M52SOB_RS09825
• Protein ID: WP_185974921.1
• Coordinates: 1940230..1941156 (-)
• Length: 309 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: A0A554X1L4
• Locus tag: M52SOB_RS09830
• Protein ID: WP_024892246.1
• Coordinates: 1941153..1941752 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M52SOB_RS09785	1935307..1935633	+	327	WP_102042177.1	helix-turn-helix transcriptional regulator	-
M52SOB_RS09790	1935623..1936516	+	894	WP_102042176.1	ImmA/IrrE family metallo-endopeptidase	-
M52SOB_RS09795	1936634..1936852	+	219	WP_072755421.1	hypothetical protein	-
M52SOB_RS09800	1936849..1937346	+	498	WP_072755420.1	DUF2924 domain-containing protein	-
M52SOB_RS09805	1937343..1938701	+	1359	WP_072755419.1	recombinase family protein	-
M52SOB_RS09810	1938698..1939129	+	432	WP_102042175.1	hypothetical protein	-
M52SOB_RS09815	1939161..1939748	-	588	WP_024892249.1	NERD domain-containing protein	-
M52SOB_RS09820	1939745..1940233	-	489	WP_024892248.1	hypothetical protein	-
M52SOB_RS09825	1940230..1941156	-	927	WP_185974921.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
M52SOB_RS09830	1941153..1941752	-	600	WP_024892246.1	AbiEi antitoxin N-terminal domain-containing protein	Antitoxin
M52SOB_RS09840	1942318..1942623	-	306	WP_131111642.1	hypothetical protein	-
M52SOB_RS09845	1942657..1944750	-	2094	WP_131112508.1	sodium:solute symporter family protein	-
M52SOB_RS09850	1944750..1945013	-	264	WP_131111643.1	DUF4212 domain-containing protein	-
M52SOB_RS09855	1945018..1946478	-	1461	WP_284155243.1	sensor histidine kinase N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	htpB	1888824..1958125	69301

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (36-259)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (8-53)

Sequences

Toxin

Protein

• Length: 309 a.a.
• Molecular weight: 34681.53 Da
• Isoelectric Point: 5.6877

>T32637 WP_185974921.1 NZ_AP019373:c1941156-1940230 [Sulfuricystis thermophila]
MNQRNMAASVRARLLNRARETRQDFNLILTRYALERLLYRLSISPHADQFLLKGALLFDLWFDIPHRPTRDADLLGFGSA
EIPHVEAAFRDICTVELDDGIRFQPDSVHAEEIRKEANYSGVRVTLIGLLDGARCHVQVDVGFGDAVTPGPEAVDYPVML
PDMPAPKLRAYPRYTVVAEKLEALVSLGIANSRMKDYFDLWILSRYTDFDGALLCKAIHATFERRRTPLPDGVPFGLSDE
FAQDRQKQTQWQAFLRKNALDELQLSEVVAGLRAFLSFPLDALQQGAAFPQTWLAGNGWMSSGEESGR

Nucleotide

• Length: 927 bp

>T32637 NZ_AP019373:c1941156-1940230 [Sulfuricystis thermophila]
ATGAACCAGCGCAACATGGCCGCCTCGGTGCGCGCCCGCCTGCTCAACCGCGCCCGCGAGACCCGACAAGACTTCAATCT
GATCTTGACCCGCTATGCGCTTGAGCGCCTGCTTTACCGGCTCAGCATCTCCCCCCACGCCGACCAGTTCCTGCTGAAAG
GTGCGCTGCTGTTCGACTTGTGGTTCGACATCCCGCATCGTCCGACACGCGACGCCGATCTGCTGGGCTTCGGCTCGGCC
GAGATCCCGCATGTCGAGGCGGCGTTTCGGGACATCTGTACGGTGGAACTGGACGACGGCATACGCTTCCAGCCTGACTC
GGTACACGCGGAGGAGATCCGCAAGGAAGCCAACTACTCCGGTGTCCGGGTCACGCTGATCGGCCTGTTGGACGGTGCCC
GATGCCACGTGCAGGTCGACGTGGGTTTCGGCGACGCCGTGACGCCCGGCCCCGAGGCCGTCGACTACCCGGTAATGCTG
CCGGACATGCCAGCCCCGAAGCTGCGCGCCTACCCCCGCTACACGGTTGTCGCCGAGAAGCTGGAGGCACTGGTGTCGCT
CGGCATCGCCAACAGCCGCATGAAGGATTACTTCGATCTCTGGATCTTGTCGCGCTACACCGACTTCGACGGCGCGCTCC
TGTGCAAGGCGATCCACGCCACCTTCGAGCGCCGCAGGACACCGCTGCCGGATGGCGTCCCTTTCGGATTGAGCGACGAA
TTCGCGCAGGATCGGCAGAAGCAGACTCAGTGGCAAGCATTCTTGAGGAAGAATGCCTTGGACGAGCTTCAGCTTTCCGA
GGTCGTTGCCGGTCTGCGTGCCTTCCTGTCATTCCCGCTGGACGCGCTCCAGCAAGGTGCTGCATTTCCGCAAACATGGC
TTGCCGGAAACGGGTGGATGTCGAGCGGCGAGGAATCGGGCCGATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22311.98 Da
• Isoelectric Point: 10.2174

>AT32637 WP_024892246.1 NZ_AP019373:c1941752-1941153 [Sulfuricystis thermophila]
MDSSHQSILDLAAQRGLIRPRDLNERGLPTIALTRLVRQGLLQRVGRGLYAIPDRAVSEHGALSEVARKHPQAIVCLLSA
LRLHELTTQSPFEVWLAIPNKARAPKMDYPPLRIVRFSGAALTEGVEEHLIDGVPVRVTNVARTVADCFKFRNKIGLDVA
LEALQESWRAKRVSMDELWRFAALCRVANVMRPYMESLS

Nucleotide

• Length: 600 bp

>AT32637 NZ_AP019373:c1941752-1941153 [Sulfuricystis thermophila]
ATGGACAGTTCGCACCAGAGCATTCTGGATCTTGCCGCCCAGCGCGGCCTTATTCGCCCACGCGATCTCAATGAGCGTGG
GCTGCCCACGATCGCCCTCACGCGGCTGGTGCGGCAAGGGCTGCTCCAGCGCGTGGGACGGGGCCTGTACGCAATTCCGG
ACCGGGCCGTCTCGGAACACGGCGCACTCTCCGAGGTGGCACGCAAGCACCCGCAAGCCATCGTCTGCCTGCTGTCGGCA
CTGCGCCTACATGAACTCACCACACAGTCGCCGTTCGAGGTCTGGCTGGCAATTCCCAACAAGGCACGCGCGCCAAAGAT
GGACTATCCCCCGCTGCGCATCGTGCGCTTCTCTGGCGCCGCGCTGACGGAGGGGGTCGAGGAGCACCTCATCGATGGTG
TGCCGGTGCGCGTGACCAACGTCGCCCGGACCGTGGCTGACTGCTTCAAGTTCCGCAACAAGATCGGCCTCGATGTCGCG
CTGGAGGCGCTACAGGAGTCCTGGCGTGCCAAGCGCGTCAGCATGGATGAACTTTGGCGTTTTGCTGCGCTGTGCCGTGT
GGCCAATGTGATGCGCCCCTACATGGAAAGCCTGTCATGA

Structures

Antitoxin

• AlphaFold DB: A0A554X1L4