Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 1940230..1941752 Replicon chromosome
Accession NZ_AP019373
Organism Sulfuricystis thermophila strain M52

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag M52SOB_RS09825 Protein ID WP_185974921.1
Coordinates 1940230..1941156 (-) Length 309 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID A0A554X1L4
Locus tag M52SOB_RS09830 Protein ID WP_024892246.1
Coordinates 1941153..1941752 (-) Length 200 a.a.

Genomic Context

M52SOB_RS09785M52SOB_RS09790M52SOB_RS09795M52SOB_RS09800M52SOB_RS09805M52SOB_RS09810M52SOB_RS09815M52SOB_RS09820M52SOB_RS09825M52SOB_RS09830M52SOB_RS09840M52SOB_RS09845M52SOB_RS09850M52SOB_RS09855
Location: 1935307..1935633 (327 bp)
Type: Others
Protein ID: WP_102042177.1
Location: 1935623..1936516 (894 bp)
Type: Others
Protein ID: WP_102042176.1
Location: 1936634..1936852 (219 bp)
Type: Others
Protein ID: WP_072755421.1
Location: 1936849..1937346 (498 bp)
Type: Others
Protein ID: WP_072755420.1
Location: 1937343..1938701 (1359 bp)
Type: Others
Protein ID: WP_072755419.1
Location: 1938698..1939129 (432 bp)
Type: Others
Protein ID: WP_102042175.1
Location: 1939161..1939748 (588 bp)
Type: Others
Protein ID: WP_024892249.1
Location: 1939745..1940233 (489 bp)
Type: Others
Protein ID: WP_024892248.1
Location: 1940230..1941156 (927 bp)
Type: Toxin
Protein ID: WP_185974921.1
Location: 1941153..1941752 (600 bp)
Type: Antitoxin
Protein ID: WP_024892246.1
Location: 1942318..1942623 (306 bp)
Type: Others
Protein ID: WP_131111642.1
Location: 1942657..1944750 (2094 bp)
Type: Others
Protein ID: WP_131112508.1
Location: 1944750..1945013 (264 bp)
Type: Others
Protein ID: WP_131111643.1
Location: 1945018..1946478 (1461 bp)
Type: Others
Protein ID: WP_284155243.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
M52SOB_RS097851935307..1935633+327WP_102042177.1helix-turn-helix transcriptional regulator-
M52SOB_RS097901935623..1936516+894WP_102042176.1ImmA/IrrE family metallo-endopeptidase-
M52SOB_RS097951936634..1936852+219WP_072755421.1hypothetical protein-
M52SOB_RS098001936849..1937346+498WP_072755420.1DUF2924 domain-containing protein-
M52SOB_RS098051937343..1938701+1359WP_072755419.1recombinase family protein-
M52SOB_RS098101938698..1939129+432WP_102042175.1hypothetical protein-
M52SOB_RS098151939161..1939748-588WP_024892249.1NERD domain-containing protein-
M52SOB_RS098201939745..1940233-489WP_024892248.1hypothetical protein-
M52SOB_RS098251940230..1941156-927WP_185974921.1nucleotidyl transferase AbiEii/AbiGii toxin family proteinToxin
M52SOB_RS098301941153..1941752-600WP_024892246.1AbiEi antitoxin N-terminal domain-containing proteinAntitoxin
M52SOB_RS098401942318..1942623-306WP_131111642.1hypothetical protein-
M52SOB_RS098451942657..1944750-2094WP_131112508.1sodium:solute symporter family protein-
M52SOB_RS098501944750..1945013-264WP_131111643.1DUF4212 domain-containing protein-
M52SOB_RS098551945018..1946478-1461WP_284155243.1sensor histidine kinase N-terminal domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage-htpB1888824..195812569301


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-259)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(8-53)


Sequences

Toxin        


Download         Length: 309 a.a.        Molecular weight: 34681.53 Da        Isoelectric Point: 5.6877

>T32637 WP_185974921.1 NZ_AP019373:c1941156-1940230 [Sulfuricystis thermophila]
MNQRNMAASVRARLLNRARETRQDFNLILTRYALERLLYRLSISPHADQFLLKGALLFDLWFDIPHRPTRDADLLGFGSA
EIPHVEAAFRDICTVELDDGIRFQPDSVHAEEIRKEANYSGVRVTLIGLLDGARCHVQVDVGFGDAVTPGPEAVDYPVML
PDMPAPKLRAYPRYTVVAEKLEALVSLGIANSRMKDYFDLWILSRYTDFDGALLCKAIHATFERRRTPLPDGVPFGLSDE
FAQDRQKQTQWQAFLRKNALDELQLSEVVAGLRAFLSFPLDALQQGAAFPQTWLAGNGWMSSGEESGR

Download         Length: 927 bp

>T32637 NZ_AP019373:c1941156-1940230 [Sulfuricystis thermophila]
ATGAACCAGCGCAACATGGCCGCCTCGGTGCGCGCCCGCCTGCTCAACCGCGCCCGCGAGACCCGACAAGACTTCAATCT
GATCTTGACCCGCTATGCGCTTGAGCGCCTGCTTTACCGGCTCAGCATCTCCCCCCACGCCGACCAGTTCCTGCTGAAAG
GTGCGCTGCTGTTCGACTTGTGGTTCGACATCCCGCATCGTCCGACACGCGACGCCGATCTGCTGGGCTTCGGCTCGGCC
GAGATCCCGCATGTCGAGGCGGCGTTTCGGGACATCTGTACGGTGGAACTGGACGACGGCATACGCTTCCAGCCTGACTC
GGTACACGCGGAGGAGATCCGCAAGGAAGCCAACTACTCCGGTGTCCGGGTCACGCTGATCGGCCTGTTGGACGGTGCCC
GATGCCACGTGCAGGTCGACGTGGGTTTCGGCGACGCCGTGACGCCCGGCCCCGAGGCCGTCGACTACCCGGTAATGCTG
CCGGACATGCCAGCCCCGAAGCTGCGCGCCTACCCCCGCTACACGGTTGTCGCCGAGAAGCTGGAGGCACTGGTGTCGCT
CGGCATCGCCAACAGCCGCATGAAGGATTACTTCGATCTCTGGATCTTGTCGCGCTACACCGACTTCGACGGCGCGCTCC
TGTGCAAGGCGATCCACGCCACCTTCGAGCGCCGCAGGACACCGCTGCCGGATGGCGTCCCTTTCGGATTGAGCGACGAA
TTCGCGCAGGATCGGCAGAAGCAGACTCAGTGGCAAGCATTCTTGAGGAAGAATGCCTTGGACGAGCTTCAGCTTTCCGA
GGTCGTTGCCGGTCTGCGTGCCTTCCTGTCATTCCCGCTGGACGCGCTCCAGCAAGGTGCTGCATTTCCGCAAACATGGC
TTGCCGGAAACGGGTGGATGTCGAGCGGCGAGGAATCGGGCCGATGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22311.98 Da        Isoelectric Point: 10.2174

>AT32637 WP_024892246.1 NZ_AP019373:c1941752-1941153 [Sulfuricystis thermophila]
MDSSHQSILDLAAQRGLIRPRDLNERGLPTIALTRLVRQGLLQRVGRGLYAIPDRAVSEHGALSEVARKHPQAIVCLLSA
LRLHELTTQSPFEVWLAIPNKARAPKMDYPPLRIVRFSGAALTEGVEEHLIDGVPVRVTNVARTVADCFKFRNKIGLDVA
LEALQESWRAKRVSMDELWRFAALCRVANVMRPYMESLS

Download         Length: 600 bp

>AT32637 NZ_AP019373:c1941752-1941153 [Sulfuricystis thermophila]
ATGGACAGTTCGCACCAGAGCATTCTGGATCTTGCCGCCCAGCGCGGCCTTATTCGCCCACGCGATCTCAATGAGCGTGG
GCTGCCCACGATCGCCCTCACGCGGCTGGTGCGGCAAGGGCTGCTCCAGCGCGTGGGACGGGGCCTGTACGCAATTCCGG
ACCGGGCCGTCTCGGAACACGGCGCACTCTCCGAGGTGGCACGCAAGCACCCGCAAGCCATCGTCTGCCTGCTGTCGGCA
CTGCGCCTACATGAACTCACCACACAGTCGCCGTTCGAGGTCTGGCTGGCAATTCCCAACAAGGCACGCGCGCCAAAGAT
GGACTATCCCCCGCTGCGCATCGTGCGCTTCTCTGGCGCCGCGCTGACGGAGGGGGTCGAGGAGCACCTCATCGATGGTG
TGCCGGTGCGCGTGACCAACGTCGCCCGGACCGTGGCTGACTGCTTCAAGTTCCGCAACAAGATCGGCCTCGATGTCGCG
CTGGAGGCGCTACAGGAGTCCTGGCGTGCCAAGCGCGTCAGCATGGATGAACTTTGGCGTTTTGCTGCGCTGTGCCGTGT
GGCCAATGTGATGCGCCCCTACATGGAAAGCCTGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A554X1L4

References