Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 796620..797144 Replicon chromosome
Accession NZ_AP019372
Organism Staphylococcus pseudintermedius strain SP79

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag GSP_RS03555 Protein ID WP_014613379.1
Coordinates 796791..797144 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag GSP_RS03550 Protein ID WP_014613378.1
Coordinates 796620..796790 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSP_RS03525 792509..792982 + 474 WP_014613373.1 PH domain-containing protein -
GSP_RS03530 792975..794504 + 1530 WP_127505013.1 PH domain-containing protein -
GSP_RS03535 794488..795006 + 519 WP_014613375.1 PH domain-containing protein -
GSP_RS03540 795003..795353 + 351 WP_014613376.1 holo-ACP synthase -
GSP_RS03545 795387..796535 + 1149 WP_065354670.1 alanine racemase -
GSP_RS03550 796620..796790 + 171 WP_014613378.1 hypothetical protein Antitoxin
GSP_RS03555 796791..797144 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GSP_RS03560 797202..798205 + 1004 Protein_701 PP2C family protein-serine/threonine phosphatase -
GSP_RS03565 798284..798610 + 327 WP_014613381.1 anti-sigma factor antagonist -
GSP_RS03570 798610..799089 + 480 WP_031253870.1 anti-sigma B factor RsbW -
GSP_RS03575 799064..799834 + 771 WP_015729428.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T32636 WP_014613379.1 NZ_AP019372:796791-797144 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T32636 NZ_AP019372:796791-797144 [Staphylococcus pseudintermedius]
ATGAAGCGCGGAGACGTTTATTTAGCAGATTTATCACCAGTACAGGGCTCTGAACAGGGGGGAGTAAGGCCCGTTGTCAT
TATTCAAAATGACACTGGTAATAAGTATAGTCCCACTGTGATTGTAGCCGCAATTACTGGTCGGATTAATAAGGCAAAGA
TACCAACGCATGTCGAAATCGAAAAAAATAAATATAAGCTCGATAAAGATTCTGTTATTTTACTAGAACAAATTCGAACA
GTCGATAAGAAACGATTAAAAGAAAAGTTAACGTTTTTGTCTGAGAAGAAGATGAAAGAAGTTAACAATGCGATTGGTAT
TAGTTTAGGACTGCACATGAATCATCATAAATAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT32636 WP_014613378.1 NZ_AP019372:796620-796790 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT32636 NZ_AP019372:796620-796790 [Staphylococcus pseudintermedius]
ATGTCAGCATTCAATCAAACAAGATTTAAAAATTTAGAACAGTCGTTAAAAGAAGGTTATGTACAGATGGCAGATTTAAA
TCTCTCCCTAGCCACTGAGGCGTATCCAGTTGAATGTGAAGCTTGCGATTGTAATGAATCACACTTGACAACTGATTACA
AGGAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References