Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-UPF0150
Location 4597451..4597884 Replicon chromosome
Accession NZ_AP019314
Organism Microcystis viridis NIES-102

Toxin (Protein)


Gene name hicA Uniprot ID B0JRI6
Locus tag myaer102_RS23820 Protein ID WP_012264433.1
Coordinates 4597660..4597884 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID I4IBE8
Locus tag myaer102_RS23815 Protein ID WP_008199545.1
Coordinates 4597451..4597663 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
myaer102_RS23785 4592981..4595152 - 2172 WP_125731822.1 glutamine synthetase III -
myaer102_RS23790 4595572..4596291 + 720 WP_125731824.1 PEP-CTERM sorting domain-containing protein -
myaer102_RS23800 4596427..4596726 - 300 WP_002763657.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
myaer102_RS23805 4596869..4597207 + 339 WP_012264431.1 hypothetical protein -
myaer102_RS23810 4597198..4597383 + 186 WP_041803782.1 hypothetical protein -
myaer102_RS23815 4597451..4597663 + 213 WP_008199545.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
myaer102_RS23820 4597660..4597884 + 225 WP_012264433.1 type II toxin-antitoxin system HicA family toxin Toxin
myaer102_RS23825 4597962..4598234 + 273 WP_012264434.1 hypothetical protein -
myaer102_RS23830 4598292..4598492 + 201 WP_008199548.1 hypothetical protein -
myaer102_RS23835 4598598..4598843 + 246 WP_002753457.1 type II toxin-antitoxin system HicB family antitoxin -
myaer102_RS23840 4598843..4599064 + 222 WP_002732388.1 type II toxin-antitoxin system HicA family toxin -
myaer102_RS23845 4599161..4600597 - 1437 WP_125731826.1 folate/biopterin family MFS transporter -
myaer102_RS23850 4601349..4601963 - 615 Protein_4462 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(9-65)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-62)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8427.96 Da        Isoelectric Point: 11.2578

>T32631 WP_012264433.1 NZ_AP019314:4597660-4597884 [Microcystis viridis NIES-102]
MSELPPIAGRQVVKALGKIGYELDRQRGSHIILRQKAYPYRRITIPDHREVAKGTLRSIIRQAGLTMAEFKTLL

Download         Length: 225 bp

>T32631 NZ_AP019314:4597660-4597884 [Microcystis viridis NIES-102]
ATGAGTGAACTCCCTCCTATCGCTGGTCGCCAAGTCGTTAAAGCACTGGGCAAGATTGGCTACGAATTAGATCGGCAGCG
AGGAAGTCATATCATACTCAGACAAAAAGCCTATCCCTATCGACGCATCACCATCCCTGACCATCGAGAAGTGGCTAAGG
GAACACTGAGATCTATCATTCGTCAAGCGGGATTGACAATGGCAGAGTTTAAAACTCTCCTTTAG

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7836.95 Da        Isoelectric Point: 3.9098

>AT32631 WP_008199545.1 NZ_AP019314:4597451-4597663 [Microcystis viridis NIES-102]
MKYRVLIEQDEDGIYVAEVPSLPGCISQGNTRFELLANIQEAIALYLESLEAHNEPIPPPISEELVEVKL

Download         Length: 213 bp

>AT32631 NZ_AP019314:4597451-4597663 [Microcystis viridis NIES-102]
ATGAAATATCGCGTCTTAATTGAGCAAGATGAAGATGGCATTTATGTGGCTGAAGTTCCCTCCCTACCCGGCTGTATTTC
TCAAGGCAATACCCGGTTCGAGTTACTCGCCAACATTCAGGAAGCAATTGCTTTATATCTAGAAAGCCTAGAAGCGCACA
ATGAACCGATTCCACCACCAATTTCTGAGGAACTGGTAGAGGTTAAATTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G9JPA5

Antitoxin

Source ID Structure
AlphaFold DB I4IBE8

References