Detailed information of TA system TA032622

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 4686550..4687182
• Replicon: chromosome
• Accession: NZ_AP019312
• Organism: Chromobacterium haemolyticum strain CH06-BL

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GYH29_RS21615
• Protein ID: WP_019103135.1
• Coordinates: 4686766..4687182 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A2T5NW37
• Locus tag: GYH29_RS21610
• Protein ID: WP_019103136.1
• Coordinates: 4686550..4686762 (+)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GYH29_RS21600	4682134..4683267	+	1134	WP_081575943.1	efflux RND transporter periplasmic adaptor subunit	-
GYH29_RS21605	4683267..4686353	+	3087	WP_161524380.1	efflux RND transporter permease subunit	-
GYH29_RS21610	4686550..4686762	+	213	WP_019103136.1	hypothetical protein	Antitoxin
GYH29_RS21615	4686766..4687182	+	417	WP_019103135.1	type II toxin-antitoxin system VapC family toxin	Toxin
GYH29_RS21620	4687188..4687685	-	498	WP_019103134.1	CNP1-like family protein	-
GYH29_RS21625	4687701..4688480	-	780	WP_019103133.1	NRDE family protein	-
GYH29_RS21630	4688670..4688900	+	231	WP_043589636.1	sulfurtransferase TusA family protein	-
GYH29_RS21635	4689100..4690137	+	1038	WP_161524381.1	dihydroorotase	-
GYH29_RS21640	4690194..4690535	-	342	WP_019101760.1	FKBP-type peptidyl-prolyl cis-trans isomerase	-
GYH29_RS21645	4690532..4690696	-	165	WP_161524382.1	hypothetical protein	-
GYH29_RS21650	4690838..4691587	+	750	WP_043589632.1	sulfite exporter TauE/SafE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15101.20 Da
• Isoelectric Point: 6.7178

>T32622 WP_019103135.1 NZ_AP019312:4686766-4687182 [Chromobacterium haemolyticum]
VYLVDTNIVSEARKGGKANAGVLAFWRSADADSLYLSAISVGEIRRGIENLKHRGDLKQAGLLEQWLDTITQEFSQRILN
FDADCAQVWGKLMSPHPQNAVDKQIAAIALIHDLTIVTRNSGDFAGTGVKLLNPFNPI

Nucleotide

• Length: 417 bp

>T32622 NZ_AP019312:4686766-4687182 [Chromobacterium haemolyticum]
GTGTATCTGGTGGACACCAATATCGTCAGCGAGGCTCGCAAAGGCGGCAAAGCCAATGCAGGCGTGCTCGCCTTCTGGCG
ATCGGCGGACGCGGACAGCCTCTATCTGTCCGCCATCAGCGTGGGGGAAATTCGCCGCGGCATAGAGAATCTCAAGCATC
GCGGCGACCTCAAGCAGGCCGGCCTGCTGGAACAATGGCTGGACACCATCACCCAGGAATTTTCCCAACGCATTCTGAAC
TTCGATGCCGATTGCGCCCAGGTATGGGGCAAGTTGATGTCCCCTCATCCCCAGAACGCCGTCGACAAGCAAATCGCCGC
CATCGCGCTGATCCACGACCTGACGATCGTGACCCGCAATAGCGGCGATTTTGCCGGCACCGGCGTCAAACTATTGAATC
CGTTCAACCCGATCTAA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7840.84 Da
• Isoelectric Point: 6.4684

>AT32622 WP_019103136.1 NZ_AP019312:4686550-4686762 [Chromobacterium haemolyticum]
MANLIVRNIDDEVAAELKRRAAAHGVSAEAEHRRILRSALLAQPKRRSFAEVLANMPDVGEDADFERSRE

Nucleotide

• Length: 213 bp

>AT32622 NZ_AP019312:4686550-4686762 [Chromobacterium haemolyticum]
ATGGCCAATCTGATCGTGCGCAATATCGACGATGAAGTCGCCGCGGAGCTCAAGCGTCGCGCGGCGGCCCACGGCGTCAG
CGCCGAAGCCGAGCATCGCCGCATTCTGCGCAGCGCCTTGCTCGCCCAACCCAAACGCCGCAGCTTTGCCGAAGTCCTGG
CCAATATGCCCGACGTGGGCGAAGACGCCGACTTCGAACGCAGCCGGGAATAG

Structures

Antitoxin

• AlphaFold DB: A0A2T5NW37