Detailed information of TA system TA032621

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-parD/RelE(toxin)
• Location: 4606700..4607253
• Replicon: chromosome
• Accession: NZ_AP019312
• Organism: Chromobacterium haemolyticum strain CH06-BL

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GYH29_RS21260
• Protein ID: WP_081575169.1
• Coordinates: 4606981..4607253 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A2T5NS08
• Locus tag: GYH29_RS21255
• Protein ID: WP_019102024.1
• Coordinates: 4606700..4606984 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GYH29_RS21230	4601839..4602918	+	1080	WP_019103142.1	ionic transporter y4hA	-
GYH29_RS21235	4603142..4603564	-	423	WP_052051917.1	nuclear transport factor 2 family protein	-
GYH29_RS21240	4603604..4604308	-	705	WP_039755028.1	DsbA family protein	-
GYH29_RS21245	4604491..4605372	-	882	WP_043589989.1	MBL fold metallo-hydrolase	-
GYH29_RS21250	4605501..4606415	+	915	WP_043589705.1	LysR family transcriptional regulator	-
GYH29_RS21255	4606700..4606984	+	285	WP_019102024.1	hypothetical protein	Antitoxin
GYH29_RS21260	4606981..4607253	+	273	WP_081575169.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
GYH29_RS21265	4607797..4608246	+	450	WP_118268387.1	hypothetical protein	-
GYH29_RS21270	4608365..4609279	-	915	WP_198001611.1	LysR family transcriptional regulator	-
GYH29_RS21275	4609374..4610387	+	1014	WP_161524357.1	zinc-binding alcohol dehydrogenase family protein	-
GYH29_RS21280	4610961..4611653	+	693	WP_019102518.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10250.79 Da
• Isoelectric Point: 6.7161

>T32621 WP_081575169.1 NZ_AP019312:4606981-4607253 [Chromobacterium haemolyticum]
MKLAWTPDAVADREAIFEYIAADNPAAALALDELFEQQASRLLLHPELGRAGRVAGTREWVLHRNYVCVYDLVTDQLRVL
RVLHVARQRP

Nucleotide

• Length: 273 bp

>T32621 NZ_AP019312:4606981-4607253 [Chromobacterium haemolyticum]
ATGAAGCTGGCTTGGACGCCTGATGCGGTGGCGGATCGCGAAGCCATTTTTGAATACATTGCAGCAGATAACCCAGCAGC
GGCTCTTGCTCTTGATGAGCTTTTTGAGCAGCAGGCCTCCCGGCTGCTTCTGCATCCTGAGTTGGGCCGGGCAGGACGTG
TTGCCGGCACTAGAGAGTGGGTTCTTCATCGCAACTATGTCTGCGTTTACGATTTAGTAACTGATCAACTCCGGGTGCTT
CGGGTTTTACATGTTGCCCGACAACGGCCTTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10962.27 Da
• Isoelectric Point: 5.9110

>AT32621 WP_019102024.1 NZ_AP019312:4606700-4606984 [Chromobacterium haemolyticum]
MSESTFTFRVDESLKQEFAKVAKLQDRTGAQLLRDFMREVVRKNEEAAEYDQWFRSQVQQGLDQANAGELLPGDQVEAHF
AAKRAELRRRMAER

Nucleotide

• Length: 285 bp

>AT32621 NZ_AP019312:4606700-4606984 [Chromobacterium haemolyticum]
ATGAGCGAGTCGACTTTTACTTTCCGTGTCGATGAGTCTCTGAAGCAGGAGTTTGCCAAGGTGGCCAAATTGCAGGATCG
CACGGGCGCCCAGCTACTCCGTGACTTTATGCGCGAAGTGGTGCGAAAGAATGAGGAGGCCGCTGAGTATGATCAGTGGT
TCCGTAGCCAGGTCCAACAGGGGCTGGACCAAGCGAATGCGGGTGAACTGCTTCCTGGCGATCAGGTAGAGGCGCATTTT
GCTGCCAAGAGGGCGGAGTTGCGCCGGAGAATGGCTGAACGATGA

Structures

Antitoxin

• AlphaFold DB: A0A2T5NS08