Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1338155..1338672 Replicon chromosome
Accession NZ_AP019312
Organism Chromobacterium haemolyticum strain CH06-BL

Toxin (Protein)


Gene name relE Uniprot ID A0A5S9EKE1
Locus tag GYH29_RS06315 Protein ID WP_019101445.1
Coordinates 1338418..1338672 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2T5NK26
Locus tag GYH29_RS06310 Protein ID WP_019101444.1
Coordinates 1338155..1338418 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GYH29_RS06285 1333355..1334290 + 936 WP_043593777.1 LysR family transcriptional regulator -
GYH29_RS06290 1334364..1335071 + 708 WP_161523376.1 hypothetical protein -
GYH29_RS06295 1335451..1335972 + 522 WP_161523377.1 hypothetical protein -
GYH29_RS06300 1336092..1336835 - 744 WP_161523378.1 HNH endonuclease -
GYH29_RS06305 1337282..1337758 + 477 WP_161523379.1 peptidylprolyl isomerase -
GYH29_RS06310 1338155..1338418 + 264 WP_019101444.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GYH29_RS06315 1338418..1338672 + 255 WP_019101445.1 Txe/YoeB family addiction module toxin Toxin
GYH29_RS06320 1338998..1339207 - 210 WP_081575980.1 membrane protein insertion efficiency factor YidD -
GYH29_RS06325 1339204..1339431 - 228 WP_146176064.1 hypothetical protein -
GYH29_RS06330 1340058..1340807 - 750 WP_081575924.1 HNH endonuclease -
GYH29_RS06335 1340969..1341679 - 711 WP_198001645.1 hypothetical protein -
GYH29_RS06340 1341721..1342395 - 675 WP_161523380.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10154.61 Da        Isoelectric Point: 8.8727

>T32619 WP_019101445.1 NZ_AP019312:1338418-1338672 [Chromobacterium haemolyticum]
MQIKFDDNAWEDYLYWQQSSKPTLKRINALIKDIQRNPFEGIGKPEPLKHQFAGFWSRRIDDEHRLVYAVLSNVLTILQC
RYHY

Download         Length: 255 bp

>T32619 NZ_AP019312:1338418-1338672 [Chromobacterium haemolyticum]
ATGCAGATCAAGTTTGATGACAACGCATGGGAGGATTACCTCTACTGGCAGCAGAGCAGCAAGCCTACCCTCAAGCGCAT
CAACGCTCTGATCAAGGACATCCAGCGCAACCCGTTTGAGGGAATCGGCAAGCCTGAGCCGCTTAAGCACCAGTTTGCTG
GCTTCTGGTCGCGTCGCATCGACGATGAGCATCGGCTGGTCTACGCTGTCCTGAGCAACGTTCTGACCATCTTGCAGTGC
CGCTACCACTACTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9740.92 Da        Isoelectric Point: 5.6293

>AT32619 WP_019101444.1 NZ_AP019312:1338155-1338418 [Chromobacterium haemolyticum]
MKALTYSHTRQHLAEVMRQVNEDRAPVIVTTQRGEPVVIMSLADYNALEETAYLTRSPENAKRLADAAARFHSGAAKERT
LLEDEGE

Download         Length: 264 bp

>AT32619 NZ_AP019312:1338155-1338418 [Chromobacterium haemolyticum]
ATGAAAGCGCTTACCTACAGCCATACCCGCCAGCACCTGGCCGAAGTCATGCGTCAAGTGAACGAAGACCGGGCGCCGGT
GATCGTCACCACCCAGCGCGGTGAACCGGTGGTGATCATGTCGCTGGCCGACTACAACGCGCTGGAAGAAACCGCCTACC
TGACGCGCTCCCCTGAAAATGCCAAGCGTCTGGCCGATGCGGCGGCAAGGTTTCACAGCGGGGCGGCCAAAGAGAGAACG
CTTCTCGAAGACGAGGGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9EKE1

Antitoxin

Source ID Structure
AlphaFold DB A0A2T5NK26

References