Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2470156..2470633 Replicon chromosome
Accession NZ_AP019306
Organism Staphylococcus aureus strain TUM9463

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag EKM74_RS13100 Protein ID WP_000052076.1
Coordinates 2470156..2470344 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag EKM74_RS13105 Protein ID WP_001059690.1
Coordinates 2470373..2470633 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKM74_RS13070 2466150..2466671 + 522 WP_000824482.1 hypothetical protein -
EKM74_RS13075 2467012..2467698 + 687 WP_000141557.1 thermonuclease family protein -
EKM74_RS13080 2468055..2468255 + 201 WP_001059082.1 cold-shock protein -
EKM74_RS13085 2468747..2468965 - 219 WP_000005886.1 hypothetical protein -
EKM74_RS13090 2469027..2469311 - 285 WP_001004399.1 hypothetical protein -
EKM74_RS13095 2469399..2469968 - 570 WP_001106654.1 hypothetical protein -
EKM74_RS13100 2470156..2470344 - 189 WP_000052076.1 hypothetical protein Toxin
EKM74_RS13105 2470373..2470633 - 261 WP_001059690.1 hypothetical protein Antitoxin
EKM74_RS13110 2470974..2471177 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
EKM74_RS13115 2471174..2471410 - 237 WP_000349581.1 hypothetical protein -
EKM74_RS13120 2471635..2472216 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
EKM74_RS13125 2472289..2472906 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
EKM74_RS13130 2473061..2473555 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
EKM74_RS13135 2473954..2474376 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
EKM74_RS13140 2474524..2475240 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T32609 WP_000052076.1 NZ_AP019306:c2470344-2470156 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T32609 NZ_AP019306:c2470344-2470156 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT32609 WP_001059690.1 NZ_AP019306:c2470633-2470373 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT32609 NZ_AP019306:c2470633-2470373 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References