Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 1222172..1222695 Replicon chromosome
Accession NZ_AP019306
Organism Staphylococcus aureus strain TUM9463

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag EKM74_RS06820 Protein ID WP_000074049.1
Coordinates 1222172..1222438 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag EKM74_RS06825 Protein ID WP_000587616.1
Coordinates 1222438..1222695 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKM74_RS06800 1217479..1218666 - 1188 WP_000026189.1 MFS transporter -
EKM74_RS06805 1219062..1219838 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
EKM74_RS06810 1219831..1220493 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
EKM74_RS06815 1220741..1221817 - 1077 WP_001076673.1 M42 family metallopeptidase -
EKM74_RS06820 1222172..1222438 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
EKM74_RS06825 1222438..1222695 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EKM74_RS06835 1223054..1223509 + 456 WP_000732076.1 DUF1307 domain-containing protein -
EKM74_RS06840 1223677..1225254 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
EKM74_RS06845 1225449..1226198 + 750 WP_000072461.1 CPBP family intramembrane metalloprotease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T32607 WP_000074049.1 NZ_AP019306:c1222438-1222172 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T32607 NZ_AP019306:c1222438-1222172 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT32607 WP_000587616.1 NZ_AP019306:c1222695-1222438 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT32607 NZ_AP019306:c1222695-1222438 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References