Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 570988..571776 Replicon chromosome
Accession NZ_AP019306
Organism Staphylococcus aureus strain TUM9463

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag EKM74_RS03005 Protein ID WP_000525015.1
Coordinates 571315..571776 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag EKM74_RS03000 Protein ID WP_000333632.1
Coordinates 570988..571302 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKM74_RS02935 566001..566264 - 264 WP_001205732.1 hypothetical protein -
EKM74_RS02940 566273..566533 - 261 WP_125571409.1 DUF1108 family protein -
EKM74_RS02945 566514..566840 - 327 WP_000165362.1 DUF2482 family protein -
EKM74_RS02950 566935..567096 - 162 WP_031926948.1 DUF1270 family protein -
EKM74_RS02955 567109..567318 - 210 WP_000455728.1 hypothetical protein -
EKM74_RS02960 567428..567613 - 186 Protein_570 phage repressor protein -
EKM74_RS02965 567670..568272 + 603 WP_033863222.1 hypothetical protein -
EKM74_RS02970 568285..568425 - 141 WP_111689342.1 hypothetical protein -
EKM74_RS02975 568409..569191 - 783 WP_111689343.1 phage antirepressor KilAC domain-containing protein -
EKM74_RS02980 569193..569378 - 186 WP_000933365.1 helix-turn-helix transcriptional regulator -
EKM74_RS02985 569824..570306 + 483 WP_000394410.1 hypothetical protein -
EKM74_RS02990 570407..570586 - 180 WP_000438352.1 hypothetical protein -
EKM74_RS02995 570600..570836 - 237 WP_001121116.1 helix-turn-helix domain-containing protein -
EKM74_RS03000 570988..571302 + 315 WP_000333632.1 helix-turn-helix domain-containing protein Antitoxin
EKM74_RS03005 571315..571776 + 462 WP_000525015.1 hypothetical protein Toxin
EKM74_RS03010 571794..572297 + 504 WP_125571271.1 hypothetical protein -
EKM74_RS03015 572555..573604 + 1050 WP_125571273.1 site-specific integrase -
EKM74_RS03060 574813..575367 - 555 WP_000132890.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / hlgA / selk 496832..575367 78535


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18019.38 Da        Isoelectric Point: 4.9167

>T32592 WP_000525015.1 NZ_AP019306:571315-571776 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILKAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T32592 NZ_AP019306:571315-571776 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAACGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCGCACAATTACGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGTGAAGAATACATATTAAAAGCAATAGAACAATATAAAAAGATATATGGTATTGGTACTC
ACTACGGCGAGTATTCTATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12091.58 Da        Isoelectric Point: 6.4736

>AT32592 WP_000333632.1 NZ_AP019306:570988-571302 [Staphylococcus aureus]
MCFSKRMKQSRERQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT32592 NZ_AP019306:570988-571302 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAGACAAGGTATGACTTTAGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCATCTT
GAAGGAGAATTGACAGATGACGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References