Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2362060..2362537 Replicon chromosome
Accession NZ_AP019305
Organism Staphylococcus aureus strain TUM9458

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag EKM72_RS12565 Protein ID WP_000052076.1
Coordinates 2362060..2362248 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag EKM72_RS12570 Protein ID WP_001059690.1
Coordinates 2362277..2362537 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKM72_RS12535 2358054..2358575 + 522 WP_000824482.1 hypothetical protein -
EKM72_RS12540 2358916..2359602 + 687 WP_000141557.1 thermonuclease family protein -
EKM72_RS12545 2359959..2360159 + 201 WP_001059082.1 cold-shock protein -
EKM72_RS12550 2360651..2360869 - 219 WP_000005886.1 hypothetical protein -
EKM72_RS12555 2360931..2361215 - 285 WP_001004399.1 hypothetical protein -
EKM72_RS12560 2361303..2361872 - 570 WP_001106654.1 hypothetical protein -
EKM72_RS12565 2362060..2362248 - 189 WP_000052076.1 hypothetical protein Toxin
EKM72_RS12570 2362277..2362537 - 261 WP_001059690.1 hypothetical protein Antitoxin
EKM72_RS12575 2362878..2363081 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
EKM72_RS12580 2363078..2363314 - 237 WP_000349581.1 hypothetical protein -
EKM72_RS12585 2363539..2364120 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
EKM72_RS12590 2364193..2364810 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
EKM72_RS12595 2364965..2365459 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
EKM72_RS12600 2365858..2366280 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
EKM72_RS12605 2366428..2367144 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 2328199..2373079 44880


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T32585 WP_000052076.1 NZ_AP019305:c2362248-2362060 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T32585 NZ_AP019305:c2362248-2362060 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT32585 WP_001059690.1 NZ_AP019305:c2362537-2362277 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT32585 NZ_AP019305:c2362537-2362277 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References