Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 572054..572842 Replicon chromosome
Accession NZ_AP019305
Organism Staphylococcus aureus strain TUM9458

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag EKM72_RS03010 Protein ID WP_000525015.1
Coordinates 572381..572842 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag EKM72_RS03005 Protein ID WP_000333632.1
Coordinates 572054..572368 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKM72_RS02940 567067..567330 - 264 WP_001205732.1 hypothetical protein -
EKM72_RS02945 567339..567599 - 261 WP_125571409.1 DUF1108 family protein -
EKM72_RS02950 567580..567906 - 327 WP_000165362.1 DUF2482 family protein -
EKM72_RS02955 568001..568162 - 162 WP_031926948.1 DUF1270 family protein -
EKM72_RS02960 568175..568384 - 210 WP_000455728.1 hypothetical protein -
EKM72_RS02965 568494..568679 - 186 Protein_571 phage repressor protein -
EKM72_RS02970 568736..569338 + 603 WP_033863222.1 hypothetical protein -
EKM72_RS02975 569351..569491 - 141 WP_111689342.1 hypothetical protein -
EKM72_RS02980 569475..570257 - 783 WP_111689343.1 phage antirepressor KilAC domain-containing protein -
EKM72_RS02985 570259..570444 - 186 WP_000933365.1 helix-turn-helix transcriptional regulator -
EKM72_RS02990 570890..571372 + 483 WP_000394410.1 hypothetical protein -
EKM72_RS02995 571473..571652 - 180 WP_000438352.1 hypothetical protein -
EKM72_RS03000 571666..571902 - 237 WP_001121116.1 helix-turn-helix domain-containing protein -
EKM72_RS03005 572054..572368 + 315 WP_000333632.1 helix-turn-helix domain-containing protein Antitoxin
EKM72_RS03010 572381..572842 + 462 WP_000525015.1 hypothetical protein Toxin
EKM72_RS03015 572860..573363 + 504 WP_125571271.1 hypothetical protein -
EKM72_RS03020 573621..574670 + 1050 WP_125571273.1 site-specific integrase -
EKM72_RS03065 575879..576433 - 555 WP_000132890.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / hlgA / selk 497898..576433 78535


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18019.38 Da        Isoelectric Point: 4.9167

>T32568 WP_000525015.1 NZ_AP019305:572381-572842 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILKAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T32568 NZ_AP019305:572381-572842 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAACGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCGCACAATTACGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGTGAAGAATACATATTAAAAGCAATAGAACAATATAAAAAGATATATGGTATTGGTACTC
ACTACGGCGAGTATTCTATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12091.58 Da        Isoelectric Point: 6.4736

>AT32568 WP_000333632.1 NZ_AP019305:572054-572368 [Staphylococcus aureus]
MCFSKRMKQSRERQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT32568 NZ_AP019305:572054-572368 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAGACAAGGTATGACTTTAGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCATCTT
GAAGGAGAATTGACAGATGACGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References