Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 572054..572842 | Replicon | chromosome |
| Accession | NZ_AP019305 | ||
| Organism | Staphylococcus aureus strain TUM9458 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | EKM72_RS03010 | Protein ID | WP_000525015.1 |
| Coordinates | 572381..572842 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | EKM72_RS03005 | Protein ID | WP_000333632.1 |
| Coordinates | 572054..572368 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EKM72_RS02940 | 567067..567330 | - | 264 | WP_001205732.1 | hypothetical protein | - |
| EKM72_RS02945 | 567339..567599 | - | 261 | WP_125571409.1 | DUF1108 family protein | - |
| EKM72_RS02950 | 567580..567906 | - | 327 | WP_000165362.1 | DUF2482 family protein | - |
| EKM72_RS02955 | 568001..568162 | - | 162 | WP_031926948.1 | DUF1270 family protein | - |
| EKM72_RS02960 | 568175..568384 | - | 210 | WP_000455728.1 | hypothetical protein | - |
| EKM72_RS02965 | 568494..568679 | - | 186 | Protein_571 | phage repressor protein | - |
| EKM72_RS02970 | 568736..569338 | + | 603 | WP_033863222.1 | hypothetical protein | - |
| EKM72_RS02975 | 569351..569491 | - | 141 | WP_111689342.1 | hypothetical protein | - |
| EKM72_RS02980 | 569475..570257 | - | 783 | WP_111689343.1 | phage antirepressor KilAC domain-containing protein | - |
| EKM72_RS02985 | 570259..570444 | - | 186 | WP_000933365.1 | helix-turn-helix transcriptional regulator | - |
| EKM72_RS02990 | 570890..571372 | + | 483 | WP_000394410.1 | hypothetical protein | - |
| EKM72_RS02995 | 571473..571652 | - | 180 | WP_000438352.1 | hypothetical protein | - |
| EKM72_RS03000 | 571666..571902 | - | 237 | WP_001121116.1 | helix-turn-helix domain-containing protein | - |
| EKM72_RS03005 | 572054..572368 | + | 315 | WP_000333632.1 | helix-turn-helix domain-containing protein | Antitoxin |
| EKM72_RS03010 | 572381..572842 | + | 462 | WP_000525015.1 | hypothetical protein | Toxin |
| EKM72_RS03015 | 572860..573363 | + | 504 | WP_125571271.1 | hypothetical protein | - |
| EKM72_RS03020 | 573621..574670 | + | 1050 | WP_125571273.1 | site-specific integrase | - |
| EKM72_RS03065 | 575879..576433 | - | 555 | WP_000132890.1 | alpha/beta hydrolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | lukD / hlgA / selk | 497898..576433 | 78535 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18019.38 Da Isoelectric Point: 4.9167
>T32568 WP_000525015.1 NZ_AP019305:572381-572842 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILKAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILKAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T32568 NZ_AP019305:572381-572842 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAACGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCGCACAATTACGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGTGAAGAATACATATTAAAAGCAATAGAACAATATAAAAAGATATATGGTATTGGTACTC
ACTACGGCGAGTATTCTATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAACGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCGCACAATTACGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGTGAAGAATACATATTAAAAGCAATAGAACAATATAAAAAGATATATGGTATTGGTACTC
ACTACGGCGAGTATTCTATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12091.58 Da Isoelectric Point: 6.4736
>AT32568 WP_000333632.1 NZ_AP019305:572054-572368 [Staphylococcus aureus]
MCFSKRMKQSRERQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
MCFSKRMKQSRERQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
Download Length: 315 bp
>AT32568 NZ_AP019305:572054-572368 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAGACAAGGTATGACTTTAGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCATCTT
GAAGGAGAATTGACAGATGACGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAGACAAGGTATGACTTTAGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCATCTT
GAAGGAGAATTGACAGATGACGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|