Detailed information of TA system TA032554

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1188990..1189488
• Replicon: chromosome
• Accession: NZ_AP019192
• Organism: Streptococcus pneumoniae strain ASP0581

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EL334_RS06330
• Protein ID: WP_001812387.1
• Coordinates: 1188990..1189244 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: EL334_RS06335
• Protein ID: WP_000208080.1
• Coordinates: 1189246..1189488 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL334_RS06325	1187029..1188915	-	1887	WP_000150984.1	Eco57I restriction-modification methylase domain-containing protein	-
EL334_RS06330	1188990..1189244	-	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EL334_RS06335	1189246..1189488	-	243	WP_000208080.1	hypothetical protein	Antitoxin
EL334_RS06340	1189579..1190388	-	810	WP_001289493.1	MBL fold metallo-hydrolase	-
EL334_RS06345	1190390..1191739	-	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
EL334_RS06350	1191732..1192436	-	705	WP_000722076.1	response regulator transcription factor	-
EL334_RS06355	1192491..1193666	-	1176	WP_000886147.1	A/G-specific adenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T32554 WP_001812387.1 NZ_AP019192:c1189244-1188990 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T32554 NZ_AP019192:c1189244-1188990 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAATCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT32554 WP_000208080.1 NZ_AP019192:c1189488-1189246 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT32554 NZ_AP019192:c1189488-1189246 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7