Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) zeta-pezA/zeta-couple_hipB
Location 1106462..1107696 Replicon chromosome
Accession NZ_AP019192
Organism Streptococcus pneumoniae strain ASP0581

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag EL334_RS05910 Protein ID WP_126432065.1
Coordinates 1106938..1107696 (+) Length 253 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag EL334_RS05905 Protein ID WP_000579623.1
Coordinates 1106462..1106938 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL334_RS05865 1102743..1103027 + 285 WP_000969645.1 hypothetical protein -
EL334_RS05870 1103041..1103337 + 297 WP_000998888.1 hypothetical protein -
EL334_RS05875 1103351..1103548 - 198 WP_074187117.1 hypothetical protein -
EL334_RS05880 1103684..1104325 + 642 WP_000933083.1 hypothetical protein -
EL334_RS05885 1104335..1105420 + 1086 WP_000401905.1 toprim domain-containing protein -
EL334_RS05890 1105471..1105704 + 234 WP_000152419.1 hypothetical protein -
EL334_RS05895 1105701..1106084 + 384 WP_000159213.1 hypothetical protein -
EL334_RS05900 1106122..1106394 + 273 WP_000495438.1 hypothetical protein -
EL334_RS05905 1106462..1106938 + 477 WP_000579623.1 helix-turn-helix domain-containing protein Antitoxin
EL334_RS05910 1106938..1107696 + 759 WP_126432065.1 zeta toxin family protein Toxin
EL334_RS05915 1108172..1108960 + 789 WP_000214003.1 hypothetical protein -
EL334_RS05920 1109199..1109447 + 249 WP_001814254.1 hypothetical protein -
EL334_RS05925 1109618..1110337 + 720 Protein_1096 type A chloramphenicol O-acetyltransferase -
EL334_RS05935 1111133..1112056 - 924 WP_000417606.1 protein rep -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) / tet(M) / cat(pC194) - 1040135..1128587 88452


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 253 a.a.        Molecular weight: 28778.64 Da        Isoelectric Point: 7.1860

>T32552 WP_126432065.1 NZ_AP019192:1106938-1107696 [Streptococcus pneumoniae]
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVNNTRQLEELAIFERIQIYQRDRGCVYDAKENTTSAADVLQELLFGEWSQVEKDML
KSGEERLKDLTN

Download         Length: 759 bp

>T32552 NZ_AP019192:1106938-1107696 [Streptococcus pneumoniae]
GTGGAAATCCAAGATTATACTGACAGTGAATTCAAACATGCTCTAGCACGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTCGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGAGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGATAGTGTAGAATACACCAAAGATTTTGCAGGTAAAATGGTAGAGTCTTTAGTAACAGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTAGCCTTGATTGCGACAAAACCTAAGCTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
CTATACGCTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTAATAA
TACACGACAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAGGTTGTGTATATGATGCAA
AAGAAAATACAACTTCAGCGGCAGATGTTCTTCAAGAGTTACTGTTTGGGGAGTGGAGTCAAGTAGAGAAGGATATGCTT
AAATCTGGAGAAGAAAGATTGAAAGATTTAACTAATTGA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18259.71 Da        Isoelectric Point: 4.4258

>AT32552 WP_000579623.1 NZ_AP019192:1106462-1106938 [Streptococcus pneumoniae]
MIGKNIKSLRKTHELTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT32552 NZ_AP019192:1106462-1106938 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGAATTAACACAACCCGAATTTGCCCGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACCGAATTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGACTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTTTTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTAGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References