32514

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 88007..89602 Replicon chromosome
Accession NZ_AP019011
Organism Fluviibacter phosphoraccumulans strain SHINM1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag SHINM1_RS00445 Protein ID WP_162050649.1
Coordinates 88271..89602 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag SHINM1_RS00440 Protein ID WP_162050650.1
Coordinates 88007..88267 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SHINM1_RS00415 (SHINM1_000790) 83701..84600 - 900 WP_162050654.1 transporter associated domain-containing protein -
SHINM1_RS00420 (SHINM1_000800) 84607..85074 - 468 WP_162050653.1 rRNA maturation RNase YbeY -
SHINM1_RS00425 (SHINM1_000810) 85084..86085 - 1002 WP_162050652.1 PhoH family protein -
SHINM1_RS00430 (SHINM1_000820) 86088..87383 - 1296 WP_242451609.1 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB -
SHINM1_RS00440 (SHINM1_000830) 88007..88267 + 261 WP_162050650.1 helix-turn-helix domain-containing protein Antitoxin
SHINM1_RS00445 (SHINM1_000840) 88271..89602 + 1332 WP_162050649.1 type II toxin-antitoxin system HipA family toxin Toxin
SHINM1_RS00450 (SHINM1_000850) 89803..90618 + 816 WP_162050648.1 DUF4239 domain-containing protein -
SHINM1_RS00455 (SHINM1_000860) 90615..90878 + 264 WP_202930741.1 hypothetical protein -
SHINM1_RS00460 (SHINM1_000870) 90875..91909 + 1035 WP_162050647.1 selenide, water dikinase SelD -
SHINM1_RS00465 (SHINM1_000880) 91921..92997 + 1077 WP_211149048.1 tRNA 2-selenouridine(34) synthase MnmH -
SHINM1_RS00470 (SHINM1_000890) 93102..94148 + 1047 WP_162050645.1 phosphate ABC transporter substrate-binding protein PstS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-66)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 49444.51 Da        Isoelectric Point: 7.0156

>T32514 WP_162050649.1 NZ_AP019011:88271-89602 [Fluviibacter phosphoraccumulans]
MGRRSLSQKLTVWMNGIQVGVWEILRQGERFTYADAWISNAQGRPLSLSLPFVPGNAPYQGEEVGYYFDNLLPDSDAIRR
RLAQRYQANGTDAFQLLAKIGRDCVGALQFLPEGEMPTDVDQIQGRPLSEAEIAQHLRRVSTDTMLGQVELDDGLRLSIA
GAQEKTAFLRHKGQWLLPQGSTPTTHIFKLPLGLVGHMQADMRTSVENEWLCSKIMATYGVPIASCEIASFEDQKALVVA
RFDRKISTDGRWIVRLPQEDFCQAMGTSPLHKYQADGGPSITSSMNLLLGSENKDEDRRNFFKTQILFWLLAATDGHGKN
FSIAHLPGGAYRATPIYDVLSAHPVLGSGKNKIPYQKAKMAMAVRGSMNHYLIDKIQRRHWISQGQQVGLSAEMTEALIE
EVISQTDTVIDRVSQLLPVDFPLDIAEAIFEGMKKQRLKLAND

Download         Length: 1332 bp

>T32514 NZ_AP019011:88271-89602 [Fluviibacter phosphoraccumulans]
ATGGGACGGCGTTCACTATCGCAAAAGCTGACGGTGTGGATGAATGGCATCCAGGTTGGCGTTTGGGAGATCTTGCGTCA
AGGTGAGCGCTTTACCTATGCGGATGCGTGGATTTCCAATGCGCAGGGACGCCCGCTGTCTTTGTCGCTCCCATTCGTGC
CGGGTAATGCGCCGTATCAAGGCGAGGAGGTTGGTTATTATTTTGACAACCTTTTGCCGGACAGCGATGCAATCCGTCGT
CGTTTGGCGCAGCGTTATCAGGCAAACGGAACAGATGCGTTTCAACTGCTGGCAAAGATTGGTCGTGATTGCGTTGGTGC
ACTTCAATTTTTGCCTGAGGGCGAGATGCCAACCGATGTTGATCAGATACAGGGCAGACCTCTAAGCGAAGCAGAGATTG
CGCAACATCTTCGACGCGTGTCGACTGATACGATGCTGGGGCAGGTTGAGCTTGACGATGGTCTGAGGCTGTCGATTGCT
GGTGCACAGGAAAAGACGGCCTTTTTGCGGCATAAGGGGCAATGGCTGCTACCGCAGGGCAGCACACCAACAACACATAT
CTTTAAGTTGCCACTGGGATTGGTAGGGCATATGCAGGCGGATATGCGCACCTCGGTTGAGAATGAGTGGCTGTGTTCAA
AAATTATGGCGACTTATGGTGTTCCGATTGCCTCATGTGAGATTGCATCTTTTGAAGATCAGAAGGCGCTGGTCGTAGCG
CGTTTTGACCGCAAAATATCAACAGACGGGCGATGGATCGTTCGTCTTCCTCAAGAAGATTTTTGCCAAGCCATGGGGAC
CTCGCCGCTACATAAGTATCAAGCCGATGGTGGGCCGAGTATTACTTCGTCTATGAACCTATTGCTGGGTTCCGAAAACA
AGGACGAAGATCGACGTAATTTTTTTAAGACGCAGATTCTATTCTGGCTATTGGCAGCCACTGATGGCCATGGAAAGAAT
TTCAGCATCGCGCATCTGCCGGGTGGGGCATATCGCGCCACCCCCATTTACGATGTGTTATCAGCGCACCCGGTATTAGG
ATCGGGTAAAAACAAGATTCCGTATCAGAAAGCCAAGATGGCGATGGCCGTGCGCGGCTCAATGAACCATTACCTGATTG
ATAAGATCCAGCGGCGTCATTGGATCTCTCAGGGGCAACAGGTTGGCCTAAGTGCTGAGATGACCGAAGCACTGATTGAA
GAAGTGATTAGTCAAACGGATACCGTGATTGATCGTGTCAGCCAGTTGCTGCCAGTAGATTTTCCGTTAGATATCGCCGA
AGCGATCTTCGAGGGAATGAAGAAGCAGCGTCTTAAGTTGGCGAACGATTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9736.27 Da        Isoelectric Point: 9.6580

>AT32514 WP_162050650.1 NZ_AP019011:88007-88267 [Fluviibacter phosphoraccumulans]
MIYPIKTLKQLPLFLKGFRKKKGLTQASMAEQLGISQQAYARFEANPETATLERLFLVLRTLDVEISLAHSDTKQADVAS
NTQEPW

Download         Length: 261 bp

>AT32514 NZ_AP019011:88007-88267 [Fluviibacter phosphoraccumulans]
ATGATTTATCCCATAAAGACGCTCAAGCAACTCCCTTTGTTCCTAAAAGGATTCAGGAAAAAAAAGGGGCTGACCCAAGC
CTCGATGGCTGAACAGCTTGGCATCAGCCAGCAGGCTTACGCGCGCTTCGAAGCTAACCCGGAGACGGCGACCTTGGAAC
GGTTATTTCTGGTTTTGCGGACGCTGGATGTTGAGATTTCGTTGGCGCACTCAGATACCAAGCAAGCCGACGTAGCAAGC
AATACCCAAGAGCCTTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References