Detailed information of TA system TA032513

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1273..1808
• Replicon: plasmid pSERAS01
• Accession: NZ_AP019010
• Organism: Serratia marcescens strain AS-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SERAS_RS24315
• Protein ID: WP_125460859.1
• Coordinates: 1273..1560 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8G2LES3
• Locus tag: SERAS_RS24320
• Protein ID: WP_038883487.1
• Coordinates: 1557..1808 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SERAS_RS24305	450..923	-	474	WP_126502312.1	hypothetical protein	-
SERAS_RS24310	943..1221	-	279	WP_126502313.1	hypothetical protein	-
SERAS_RS24315	1273..1560	-	288	WP_125460859.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SERAS_RS24320	1557..1808	-	252	WP_038883487.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SERAS_RS24325	1903..2349	-	447	WP_038883484.1	hypothetical protein	-
SERAS_RS24330	3288..3644	-	357	WP_126502314.1	hypothetical protein	-
SERAS_RS24335	3703..4440	-	738	WP_126502315.1	plasmid SOS inhibition protein A	-
SERAS_RS24340	4437..4901	-	465	WP_126502316.1	conjugation system SOS inhibitor PsiB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	pilW	1..104121	104121

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10891.93 Da
• Isoelectric Point: 10.2278

>T32513 WP_125460859.1 NZ_AP019010:c1560-1273 [Serratia marcescens]
MTYTVKFRESALKEWGKLDKSLQQQFAKKLKKCCENPHIPSAKLRGMPGCYKIKLRASGFRLVYEVIDDCLIIAVVAVGK
RERGDVYQLASERLK

Nucleotide

• Length: 288 bp

>T32513 NZ_AP019010:c1560-1273 [Serratia marcescens]
ATGACGTATACGGTCAAATTTCGTGAATCCGCGCTGAAAGAGTGGGGCAAGCTGGACAAGTCGCTACAGCAGCAGTTCGC
TAAAAAGCTGAAAAAATGCTGCGAGAACCCGCATATACCCTCGGCAAAACTACGGGGGATGCCGGGGTGTTACAAAATCA
AGCTGCGCGCCTCGGGTTTTCGTCTGGTTTATGAGGTGATCGACGATTGCCTGATTATCGCGGTGGTTGCCGTTGGCAAA
CGTGAGCGCGGTGATGTGTACCAGTTGGCCAGCGAACGTCTTAAGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9182.46 Da
• Isoelectric Point: 4.0338

>AT32513 WP_038883487.1 NZ_AP019010:c1808-1557 [Serratia marcescens]
MPNIILSDTSASISELKKNPMETVGAGAGFPVAILNRNKPEFYCVPAALYEQMLDALDDQELVRLVNERRSEALVDIDLD
QFA

Nucleotide

• Length: 252 bp

>AT32513 NZ_AP019010:c1808-1557 [Serratia marcescens]
ATGCCAAATATCATTTTGAGTGACACAAGCGCTAGCATCAGCGAGCTGAAGAAAAACCCTATGGAAACCGTTGGCGCCGG
TGCCGGTTTTCCTGTGGCCATACTGAACCGCAATAAGCCAGAATTTTATTGTGTGCCGGCGGCGCTCTACGAGCAAATGC
TCGATGCCCTCGATGATCAGGAGCTGGTGAGATTGGTCAATGAGCGCCGTAGCGAAGCGCTGGTTGATATCGATCTGGAT
CAGTTCGCATGA