Detailed information of TA system TA032509

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 4244879..4245351
• Replicon: chromosome
• Accession: NZ_AP019009
• Organism: Serratia marcescens strain AS-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5C7D428
• Locus tag: SERAS_RS20305
• Protein ID: WP_049208401.1
• Coordinates: 4244879..4245154 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8G2LC23
• Locus tag: SERAS_RS20310
• Protein ID: WP_016930068.1
• Coordinates: 4245160..4245351 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SERAS_RS20280	4240198..4241478	-	1281	WP_028127378.1	polysaccharide deacetylase family protein	-
SERAS_RS20285	4241656..4242426	-	771	WP_004937535.1	ABC transporter permease	-
SERAS_RS20290	4242423..4243346	-	924	WP_015379030.1	ABC transporter ATP-binding protein	-
SERAS_RS20295	4243557..4244213	+	657	WP_016930066.1	carbonate dehydratase	-
SERAS_RS20300	4244252..4244788	-	537	WP_004937527.1	hypoxanthine phosphoribosyltransferase	-
SERAS_RS20305	4244879..4245154	-	276	WP_049208401.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SERAS_RS20310	4245160..4245351	-	192	WP_016930068.1	hypothetical protein	Antitoxin
SERAS_RS20315	4245457..4247100	-	1644	WP_049300404.1	multicopper oxidase CueO	-
SERAS_RS20320	4247317..4247664	+	348	WP_033634347.1	YacC family pilotin-like protein	-
SERAS_RS20325	4247789..4248652	+	864	WP_016930071.1	polyamine aminopropyltransferase	-
SERAS_RS20330	4248680..4249474	+	795	WP_004937510.1	adenosylmethionine decarboxylase	-
SERAS_RS20335	4249507..4249869	-	363	WP_016930072.1	protein YacL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10410.13 Da
• Isoelectric Point: 6.8785

>T32509 WP_049208401.1 NZ_AP019009:c4245154-4244879 [Serratia marcescens]
MLTVKWTDEAKTGLYTLLAFIAERNPLAAEALLQRIEESVIPLAEHPYLFRPGRVNGTREMVVHPNYIVVYRVLAAHIEI
VSVLHARQEYP

Nucleotide

• Length: 276 bp

>T32509 NZ_AP019009:c4245154-4244879 [Serratia marcescens]
ATGTTAACCGTCAAATGGACTGACGAAGCAAAAACGGGTTTATATACGCTGCTGGCTTTTATCGCTGAGCGAAATCCACT
TGCCGCTGAGGCTTTGTTACAACGCATTGAAGAGTCGGTTATCCCGTTAGCGGAACATCCTTATCTATTCCGGCCAGGCA
GGGTGAACGGGACTCGTGAAATGGTTGTTCATCCTAATTACATTGTGGTTTACCGCGTGCTGGCTGCACATATTGAAATA
GTGAGTGTCCTGCACGCTCGTCAGGAATACCCTTAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7178.94 Da
• Isoelectric Point: 5.6492

>AT32509 WP_016930068.1 NZ_AP019009:c4245351-4245160 [Serratia marcescens]
MPTKLDPIVSEFETQEQADSYDRWFRSTVESSINSDSSRIPHDEVMAGARHIIEQAKAKRKSA

Nucleotide

• Length: 192 bp

>AT32509 NZ_AP019009:c4245351-4245160 [Serratia marcescens]
ATGCCGACAAAATTGGATCCCATCGTTTCTGAGTTTGAGACTCAAGAGCAGGCTGATAGCTACGATCGTTGGTTCAGAAG
CACCGTGGAATCTTCCATCAATAGCGACTCCTCCCGTATCCCCCATGACGAAGTCATGGCCGGCGCTCGTCACATTATCG
AGCAGGCGAAAGCCAAAAGAAAATCGGCCTGA

Structures

Toxin

• AlphaFold DB: A0A5C7D428