Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3679160..3679722 Replicon chromosome
Accession NZ_AP019009
Organism Serratia marcescens strain AS-1

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag SERAS_RS17640 Protein ID WP_117287401.1
Coordinates 3679160..3679516 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag SERAS_RS17645 Protein ID WP_004936539.1
Coordinates 3679513..3679722 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERAS_RS17620 3674896..3675693 - 798 WP_117287398.1 energy transducer TonB -
SERAS_RS17625 3675796..3676635 - 840 WP_117287399.1 ChaN family lipoprotein -
SERAS_RS17630 3676813..3678222 + 1410 WP_033639696.1 S-methylmethionine permease -
SERAS_RS17635 3678212..3679150 + 939 WP_117287400.1 homocysteine S-methyltransferase -
SERAS_RS17640 3679160..3679516 - 357 WP_117287401.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
SERAS_RS17645 3679513..3679722 - 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
SERAS_RS17650 3679832..3682111 - 2280 WP_016926766.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
SERAS_RS17660 3682480..3682857 - 378 WP_028127771.1 DUF2570 family protein -
SERAS_RS17665 3682854..3683255 - 402 WP_049299551.1 M15 family metallopeptidase -
SERAS_RS17670 3683245..3683571 - 327 WP_004936551.1 phage holin, lambda family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13193.95 Da        Isoelectric Point: 4.9139

>T32506 WP_117287401.1 NZ_AP019009:c3679516-3679160 [Serratia marcescens]
MIFLTAEDIAEFNAEIVPHGRQEGSKVEAVANRVLNAYHYENVTDVYRLAALYLITISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRRLTE

Download         Length: 357 bp

>T32506 NZ_AP019009:c3679516-3679160 [Serratia marcescens]
ATGATCTTTTTGACCGCAGAGGATATTGCGGAGTTCAATGCTGAAATTGTGCCTCACGGCCGCCAGGAAGGCAGCAAAGT
TGAGGCTGTAGCCAACCGCGTGCTCAATGCTTACCACTACGAGAACGTCACAGACGTATACCGCTTGGCCGCGCTCTATC
TCATCACCATCAGCCACGGTCACATTTTTCTTGATGGCAACAAACGTACGGCCTTCCAAAGCATGGCGCTATTTCTCGGT
ATTAATGGCATTGCACTGCGGGAAGACGCAGAACTGGTCGAAATTACGGTTGAAGCAGCTCAAGGCCGCCTCAACGTAGA
ACAAGCCGCTGAACACTTACGCCGGCTAACCGAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT32506 WP_004936539.1 NZ_AP019009:c3679722-3679513 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT32506 NZ_AP019009:c3679722-3679513 [Serratia marcescens]
ATGACTACGATTAGCTATACGGCGGCGAGAAACAATTTGGCCGAGGTGCTTTTGGAAGCGCAAAAACAGCCGGTGGAAGT
GACGCGCCGCGGACACGATGAGGTTTACATCATCAGTAAGGCCGACTATGAGGTTTTGGTCAAAGCCAAAGTGAAAGCGC
GCATTCAGGCTAAACACGCGGATACGATTAAGGCGCTGGCGAATAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References