Detailed information of TA system TA032496

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1693669..1694194
• Replicon: chromosome
• Accession: NZ_AP019009
• Organism: Serratia marcescens strain AS-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A8G2G914
• Locus tag: SERAS_RS08100
• Protein ID: WP_016928357.1
• Coordinates: 1693669..1693953 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A542C2P2
• Locus tag: SERAS_RS08105
• Protein ID: WP_016928356.1
• Coordinates: 1693943..1694194 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SERAS_RS08075	1688929..1690062	+	1134	WP_033640832.1	putrescine ABC transporter ATP-binding subunit PotG	-
SERAS_RS08080	1690087..1691049	+	963	WP_016928361.1	putrescine ABC transporter permease PotH	-
SERAS_RS08085	1691046..1691891	+	846	WP_016928360.1	putrescine ABC transporter permease PotI	-
SERAS_RS08090	1691996..1692475	+	480	WP_028127974.1	YbjO family protein	-
SERAS_RS08095	1692545..1693672	+	1128	WP_117286962.1	23S rRNA (uracil(747)-C(5))-methyltransferase RlmC	-
SERAS_RS08100	1693669..1693953	-	285	WP_016928357.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SERAS_RS08105	1693943..1694194	-	252	WP_016928356.1	prevent-host-death protein	Antitoxin
SERAS_RS08110	1694296..1695030	-	735	WP_016928355.1	arginine ABC transporter substrate-binding protein	-
SERAS_RS08115	1695230..1695898	-	669	WP_033637817.1	arginine ABC transporter permease ArtM	-
SERAS_RS08120	1695898..1696614	-	717	WP_028127976.1	arginine ABC transporter permease ArtQ	-
SERAS_RS08125	1696624..1697355	-	732	WP_004928409.1	arginine ABC transporter substrate-binding protein	-
SERAS_RS08130	1697388..1698116	-	729	WP_117287118.1	arginine ABC transporter ATP-binding protein ArtP	-
SERAS_RS08135	1698380..1698922	-	543	WP_097102449.1	lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10775.89 Da
• Isoelectric Point: 10.6941

>T32496 WP_016928357.1 NZ_AP019009:c1693953-1693669 [Serratia marcescens]
MTYKLEFEEHALKEFKKLSPAIREQFKKKLASVLVNPHVPANKLAGLPDCYKIKLRASGFRLVYRIMETEIVVLVLSVGK
RERSAAYTAAKKRL

Nucleotide

• Length: 285 bp

>T32496 NZ_AP019009:c1693953-1693669 [Serratia marcescens]
ATGACTTATAAGCTTGAATTCGAAGAACACGCACTGAAGGAATTTAAAAAACTGTCCCCGGCGATCCGGGAACAGTTCAA
AAAAAAGCTGGCATCCGTGTTGGTTAATCCCCACGTCCCCGCCAACAAACTCGCCGGTTTGCCTGATTGCTACAAAATCA
AACTCAGAGCCTCAGGCTTTCGTTTGGTGTATCGCATCATGGAGACGGAGATCGTGGTTCTGGTCCTTTCTGTGGGCAAA
CGCGAACGTTCAGCGGCTTACACGGCTGCCAAAAAGCGCCTTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9108.39 Da
• Isoelectric Point: 4.5203

>AT32496 WP_016928356.1 NZ_AP019009:c1694194-1693943 [Serratia marcescens]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDLELAEIVRSRMNGKRIKVNL
DDL

Nucleotide

• Length: 252 bp

>AT32496 NZ_AP019009:c1694194-1693943 [Serratia marcescens]
ATGACGGTTCAACCCATTCTCGCCGACTCCGCAGTCAGCATCAGCGATTTTAAAAAATCGCCCAACGCCGCCCTTAAAGA
GGCACAAGGGCAACCGGTCGCCGTCCTGACCAACGGTAAGATTTCGGGATATTACGTCTCTCCGGAAACCTGGGAGGCGA
TCGCGGAGTACCTGGAAGATCTCGAACTCGCTGAAATCGTTCGTTCACGGATGAACGGCAAACGCATTAAGGTCAATTTG
GATGACTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A542C2P2