Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1564028..1564576 Replicon chromosome
Accession NZ_AP019009
Organism Serratia marcescens strain AS-1

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag SERAS_RS07515 Protein ID WP_028127948.1
Coordinates 1564274..1564576 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag SERAS_RS07510 Protein ID WP_025302143.1
Coordinates 1564028..1564264 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERAS_RS07495 1560515..1562050 + 1536 WP_016928459.1 glutathione ABC transporter substrate-binding protein GsiB -
SERAS_RS07500 1562103..1563023 + 921 WP_016928458.1 glutathione ABC transporter permease GsiC -
SERAS_RS07505 1563033..1563941 + 909 WP_172962806.1 glutathione ABC transporter permease GsiD -
SERAS_RS07510 1564028..1564264 + 237 WP_025302143.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
SERAS_RS07515 1564274..1564576 + 303 WP_028127948.1 CcdB family protein Toxin
SERAS_RS07520 1564612..1565454 - 843 WP_015377214.1 S-formylglutathione hydrolase -
SERAS_RS07525 1565469..1566593 - 1125 WP_016928454.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
SERAS_RS07530 1566624..1567544 - 921 WP_016928453.1 LysR family transcriptional regulator -
SERAS_RS07535 1567650..1568807 + 1158 WP_079450985.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-99)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11210.98 Da        Isoelectric Point: 5.0196

>T32495 WP_028127948.1 NZ_AP019009:1564274-1564576 [Serratia marcescens]
ITVYDNTYPASAYPYLLDVQSDLIDVLSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQIGKAVG
NVNEHRNQIKAAIDFLIDGF

Download         Length: 303 bp

>T32495 NZ_AP019009:1564274-1564576 [Serratia marcescens]
ATTACCGTATATGACAATACGTATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGATGTCCT
CTCGACCCGGTTAATGATCCCTCTTTATGCTTTGGATAACGTCAGGGTTAAAATTTCTGCACGTTTATGCCCGGAGATTG
AGGTCAACGGCGAAAAGTTTCTTGTTATGACGCATGAGATGGCTGCCGTACGTATTTCGCAGATTGGGAAGGCCGTTGGT
AATGTCAATGAGCACAGGAATCAAATTAAAGCCGCTATCGATTTTCTGATTGATGGCTTTTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8967.04 Da        Isoelectric Point: 5.0807

>AT32495 WP_025302143.1 NZ_AP019009:1564028-1564264 [Serratia marcescens]
MANSNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp

>AT32495 NZ_AP019009:1564028-1564264 [Serratia marcescens]
ATGGCAAATAGCAATGTGACGAAAAAGACAGTCAACGTAACCATCGATCGCGATCTTTTCCAGCGCGCAAAATCCCTGGG
CGTCAATGTGTCATCCGTATTGACAGACGCATTGAGCGTCCGCGTCAGGGATATTGAGATTCAACAGTGGCGCGAGCAAA
ATCGCGCGGCGTTAGAAGAACTTAATCGTATCACTGAAGAAAATGGTTTGTTGTCTGATGAATATCGGACATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References