Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1090515..1091136 Replicon chromosome
Accession NZ_AP019009
Organism Serratia marcescens strain AS-1

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag SERAS_RS05150 Protein ID WP_004940313.1
Coordinates 1090515..1090718 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag SERAS_RS05155 Protein ID WP_004940312.1
Coordinates 1090768..1091136 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERAS_RS05120 1086216..1086554 + 339 WP_004940327.1 P-II family nitrogen regulator -
SERAS_RS05125 1086590..1087876 + 1287 WP_004940322.1 ammonium transporter AmtB -
SERAS_RS05130 1087967..1088830 - 864 WP_117287064.1 acyl-CoA thioesterase II -
SERAS_RS05135 1089061..1089552 + 492 WP_016928846.1 YbaY family lipoprotein -
SERAS_RS05140 1089617..1089931 - 315 WP_004940317.1 MGMT family protein -
SERAS_RS05150 1090515..1090718 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
SERAS_RS05155 1090768..1091136 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
SERAS_RS05160 1091295..1091648 - 354 WP_016928845.1 hypothetical protein -
SERAS_RS05165 1092053..1092766 + 714 WP_028128219.1 ABC transporter ATP-binding protein -
SERAS_RS05170 1092763..1093620 + 858 WP_117287063.1 metal ABC transporter permease -
SERAS_RS05175 1093646..1094524 + 879 WP_016928843.1 metal ABC transporter substrate-binding protein -
SERAS_RS05180 1094632..1094772 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
SERAS_RS05185 1094785..1095039 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T32494 WP_004940313.1 NZ_AP019009:c1090718-1090515 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T32494 NZ_AP019009:c1090718-1090515 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT32494 WP_004940312.1 NZ_AP019009:c1091136-1090768 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT32494 NZ_AP019009:c1091136-1090768 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGGCACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCATCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCTGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTATGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References