Detailed information of TA system TA032493

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 4093980..4094893
• Replicon: chromosome
• Accession: NZ_AP019007
• Organism: Enterobacter oligotrophicus strain CCA6

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: EoCCA6_RS19590
• Protein ID: WP_152084070.1
• Coordinates: 4093980..4094453 (-)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: EoCCA6_RS19595
• Protein ID: WP_152084071.1
• Coordinates: 4094450..4094893 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EoCCA6_RS19570	4090140..4091450	+	1311	WP_152084066.1	type I-F CRISPR-associated protein Csy1	-
EoCCA6_RS19575	4091447..4092382	+	936	WP_152084067.1	type I-F CRISPR-associated protein Csy2	-
EoCCA6_RS19580	4092396..4093394	+	999	WP_152084068.1	type I-F CRISPR-associated protein Csy3	-
EoCCA6_RS19585	4093404..4093958	+	555	WP_152084069.1	type I-F CRISPR-associated endoribonuclease Cas6/Csy4	-
EoCCA6_RS19590	4093980..4094453	-	474	WP_152084070.1	RES domain-containing protein	Toxin
EoCCA6_RS19595	4094450..4094893	-	444	WP_152084071.1	DUF2384 domain-containing protein	Antitoxin
EoCCA6_RS19600	4095452..4095670	-	219	WP_002211347.1	translation initiation factor IF-1	-
EoCCA6_RS19605	4095955..4096659	-	705	WP_152084072.1	leucyl/phenylalanyl-tRNA--protein transferase	-
EoCCA6_RS19610	4096706..4098427	-	1722	WP_152084073.1	cysteine/glutathione ABC transporter ATP-binding protein/permease CydC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-144)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17547.89 Da
• Isoelectric Point: 5.4985

>T32493 WP_152084070.1 NZ_AP019007:c4094453-4093980 [Enterobacter oligotrophicus]
VIFYRLVTGRYASEAWSGSGANQYGGRWNHKGHPAVYVSTAISLASLEILVHVKKDTVLNQYQLFSIDIPDDQIDYLDKA
WLPEDWQENPAPVSTMDLGTGWLQANSALALILPSCIIPYENNAILNPLHPAFHKTLNSVQQLPFNFDIRLAEKTAP

Nucleotide

• Length: 474 bp

>T32493 NZ_AP019007:c4094453-4093980 [Enterobacter oligotrophicus]
GTGATTTTTTATCGTCTGGTGACAGGACGTTATGCCAGCGAAGCGTGGAGTGGTAGCGGCGCAAACCAGTATGGTGGTCG
CTGGAATCATAAAGGACATCCTGCCGTCTACGTATCCACCGCCATCTCGCTGGCATCGCTCGAAATTTTGGTGCACGTGA
AAAAAGACACCGTGCTGAATCAGTATCAACTGTTCAGTATTGATATCCCGGATGACCAGATTGACTACCTGGACAAAGCC
TGGTTGCCCGAGGATTGGCAGGAAAATCCGGCACCGGTATCAACGATGGATCTGGGAACCGGTTGGTTGCAGGCGAACAG
TGCGCTCGCGCTTATCTTACCTTCCTGCATCATTCCTTATGAAAACAACGCCATACTTAACCCATTACATCCGGCATTCC
ACAAAACACTCAATTCTGTCCAGCAGCTCCCTTTTAATTTCGATATTCGTCTGGCAGAGAAAACCGCACCCTGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16366.66 Da
• Isoelectric Point: 8.5364

>AT32493 WP_152084071.1 NZ_AP019007:c4094893-4094450 [Enterobacter oligotrophicus]
MRTWVPAQKPADNALWRYAGLPANRGMRLVEYLNQGLPVSILDNIHEWTSMSKADILRVTGINERNVARRKSAGRTLTPD
ESERVARFVRVLDAAVDYFGSKEEAWNWLQAPVRGLGNVAPVNLIATETGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT32493 NZ_AP019007:c4094893-4094450 [Enterobacter oligotrophicus]
ATGAGAACATGGGTTCCCGCGCAGAAACCTGCTGACAACGCGCTTTGGCGCTATGCCGGTTTACCTGCAAACCGTGGTAT
GCGGTTAGTTGAATACCTCAATCAAGGTTTACCCGTCAGTATCCTCGATAACATTCATGAATGGACGTCGATGTCGAAAG
CGGACATCCTTCGCGTGACGGGGATTAACGAGCGCAATGTCGCTCGCCGCAAAAGCGCAGGGCGAACGCTGACGCCCGAT
GAAAGCGAGCGCGTGGCACGTTTCGTGCGTGTGCTGGATGCTGCTGTCGATTATTTTGGTAGTAAAGAGGAAGCATGGAA
CTGGCTGCAAGCACCGGTGCGTGGGCTTGGGAATGTTGCGCCAGTCAACCTGATTGCCACTGAAACCGGCGCGCTGGAAG
TCACCGATTTGATTGGTCGTCTGGAACACGGAGTGTTTGCGTGA