Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 2533439..2534055 Replicon chromosome
Accession NZ_AP019007
Organism Enterobacter oligotrophicus strain CCA6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EoCCA6_RS12180 Protein ID WP_152082872.1
Coordinates 2533684..2534055 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EoCCA6_RS12175 Protein ID WP_152082871.1
Coordinates 2533439..2533681 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EoCCA6_RS12145 2528493..2529293 + 801 WP_152082866.1 DeoR/GlpR family DNA-binding transcription regulator -
EoCCA6_RS12150 2529413..2530012 + 600 WP_152082867.1 glucose-1-phosphatase -
EoCCA6_RS12155 2530006..2530887 + 882 WP_152082868.1 virulence factor BrkB family protein -
EoCCA6_RS12160 2530884..2531321 + 438 WP_008501836.1 D-tyrosyl-tRNA(Tyr) deacylase -
EoCCA6_RS12165 2531366..2532307 + 942 WP_167515542.1 fatty acid biosynthesis protein FabY -
EoCCA6_RS12170 2532319..2533236 - 918 WP_152082870.1 alpha/beta hydrolase -
EoCCA6_RS12175 2533439..2533681 + 243 WP_152082871.1 ribbon-helix-helix protein, CopG family Antitoxin
EoCCA6_RS12180 2533684..2534055 + 372 WP_152082872.1 type II toxin-antitoxin system VapC family toxin Toxin
EoCCA6_RS12185 2534095..2535024 - 930 WP_152082873.1 formate dehydrogenase accessory protein FdhE -
EoCCA6_RS12190 2535021..2535656 - 636 WP_008501832.1 formate dehydrogenase cytochrome b556 subunit -
EoCCA6_RS12195 2535653..2536555 - 903 WP_152082874.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13589.69 Da        Isoelectric Point: 6.6359

>T32489 WP_152082872.1 NZ_AP019007:2533684-2534055 [Enterobacter oligotrophicus]
MEHMAVFDTNILIDLFNNRVEAADTIDCTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
ERHGMKLPDAIILATAQSRNCPLISRNTKDFAGIAGVVSPYQL

Download         Length: 372 bp

>T32489 NZ_AP019007:2533684-2534055 [Enterobacter oligotrophicus]
ATGGAACACATGGCGGTGTTTGATACCAATATTCTCATCGATCTCTTTAACAATCGTGTTGAAGCTGCGGATACGATTGA
TTGCACAGCTTCGCATCGGGCCATTAGCCTAATCACATGGATGGAAGTCATGGTAGGTGCGCGCAGACATGGTCATGAAG
CGAAAACGGCGGCCGTAATGGGCGCTTTTGAGATTATTGACGTTTCAAGGGATATTGCTGAAAGAAGCGTCTTGCTCCGC
GAGAGACACGGGATGAAACTGCCCGATGCCATTATTCTGGCTACTGCTCAGAGCAGAAATTGCCCGCTAATTTCGCGCAA
CACAAAAGACTTTGCCGGAATCGCAGGGGTCGTCTCTCCCTACCAACTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9490.73 Da        Isoelectric Point: 4.2910

>AT32489 WP_152082871.1 NZ_AP019007:2533439-2533681 [Enterobacter oligotrophicus]
MSLLAELDMGRILIDLSDDVIQRLDHLKQLRNQPRAELLREAIEQYLDQQSSLVIRDALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT32489 NZ_AP019007:2533439-2533681 [Enterobacter oligotrophicus]
ATGAGTCTTTTGGCGGAACTTGATATGGGCAGAATACTGATTGATTTGTCAGATGACGTAATTCAACGGCTTGATCACCT
TAAGCAGCTGCGGAACCAGCCGCGTGCCGAATTGCTTCGGGAAGCAATTGAACAATATCTCGACCAGCAGAGTTCGTTGG
TTATCCGCGATGCGCTTGGCCTGTGGGGAAACCAGCAGGAAGATGGGCTTGAGTATGAACGTAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References