32487

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 2390484..2391145 Replicon chromosome
Accession NZ_AP019007
Organism Enterobacter oligotrophicus strain CCA6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EoCCA6_RS11495 Protein ID WP_152082764.1
Coordinates 2390484..2390882 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EoCCA6_RS11500 Protein ID WP_152082765.1
Coordinates 2390879..2391145 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EoCCA6_RS11470 2385823..2386887 + 1065 WP_152082760.1 fimbrial protein -
EoCCA6_RS11475 2386931..2387566 - 636 WP_152084444.1 response regulator transcription factor -
EoCCA6_RS11480 2388144..2388764 + 621 WP_152082761.1 response regulator transcription factor -
EoCCA6_RS11485 2388840..2389520 + 681 WP_152082762.1 EAL domain-containing protein -
EoCCA6_RS11490 2389531..2390331 - 801 WP_152082763.1 lipoprotein NlpA -
EoCCA6_RS11495 2390484..2390882 - 399 WP_152082764.1 type II toxin-antitoxin system VapC family toxin Toxin
EoCCA6_RS11500 2390879..2391145 - 267 WP_152082765.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EoCCA6_RS11505 2391263..2392777 - 1515 WP_152082766.1 MFS transporter -
EoCCA6_RS11510 2392856..2393503 + 648 WP_152082767.1 TetR/AcrR family transcriptional regulator -
EoCCA6_RS11520 2393780..2394349 + 570 WP_152082768.1 TetR/AcrR family transcriptional regulator -
EoCCA6_RS11525 2394498..2395619 + 1122 WP_152082769.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14486.68 Da        Isoelectric Point: 4.9188

>T32487 WP_152082764.1 NZ_AP019007:c2390882-2390484 [Enterobacter oligotrophicus]
MRHMLDTNIVSHLFKKHPEVVTRMACLAPGDVCISSITEAELLYGADKKQSIGLKETILSFLETITICDWDSEAAATYGE
LRAAMEKKGKVMGDLDQLIAAHAISRGTTIVTNDRAFGMVQDLTVEDWTTVA

Download         Length: 399 bp

>T32487 NZ_AP019007:c2390882-2390484 [Enterobacter oligotrophicus]
ATGAGGCATATGCTTGATACGAATATTGTGAGCCATCTATTTAAAAAACATCCTGAAGTTGTCACCCGTATGGCTTGTTT
GGCTCCAGGGGATGTCTGTATTTCGAGCATCACGGAAGCGGAATTACTCTATGGTGCCGATAAGAAGCAGAGCATCGGCC
TGAAAGAGACAATATTATCTTTTCTTGAAACCATCACTATCTGCGACTGGGATAGCGAAGCCGCAGCCACCTATGGCGAG
CTGCGTGCGGCAATGGAAAAGAAAGGGAAAGTGATGGGGGATCTCGATCAGTTGATTGCTGCGCATGCTATTAGCCGGGG
CACGACGATTGTGACTAACGATCGTGCGTTCGGGATGGTGCAGGATCTCACGGTTGAGGACTGGACTACCGTAGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9987.43 Da        Isoelectric Point: 9.7504

>AT32487 WP_152082765.1 NZ_AP019007:c2391145-2390879 [Enterobacter oligotrophicus]
MERTAKLIKKGRKQVVVLPAEFAFDAESVYIRRDEAGNVVLTAKAAQVKSWDNFFRLLENTSVPDSFLNKEERKQSVTKR
DPLDGVCS

Download         Length: 267 bp

>AT32487 NZ_AP019007:c2391145-2390879 [Enterobacter oligotrophicus]
ATGGAGCGCACAGCAAAACTGATCAAAAAGGGGCGAAAGCAGGTTGTTGTTCTGCCCGCTGAGTTCGCATTTGATGCAGA
GAGTGTCTACATCCGCCGTGATGAGGCAGGGAATGTTGTTTTGACGGCAAAGGCTGCTCAGGTAAAAAGCTGGGATAATT
TCTTCCGGCTTCTGGAAAATACCAGTGTGCCTGATTCATTTCTGAACAAGGAGGAGAGAAAGCAGAGTGTGACGAAAAGA
GACCCTCTGGATGGGGTTTGTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References