Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1626775..1627437 Replicon chromosome
Accession NZ_AP018938
Organism Streptococcus pneumoniae strain ATCC 49619

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EL263_RS08610 Protein ID WP_172592534.1
Coordinates 1627264..1627437 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag EL263_RS08605 Protein ID WP_000961810.1
Coordinates 1626775..1627227 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL263_RS08575 1622154..1622897 - 744 WP_001188203.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
EL263_RS08580 1622899..1623849 - 951 WP_050072374.1 50S ribosomal protein L11 methyltransferase -
EL263_RS08585 1623985..1624501 - 517 Protein_1629 GNAT family N-acetyltransferase -
EL263_RS08590 1624498..1624926 - 429 WP_050072375.1 NUDIX hydrolase -
EL263_RS08595 1624928..1625995 - 1068 WP_000719721.1 M50 family metallopeptidase -
EL263_RS08600 1626014..1626484 - 471 WP_054387465.1 DUF3013 family protein -
EL263_RS08605 1626775..1627227 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EL263_RS08610 1627264..1627437 - 174 WP_172592534.1 type II toxin-antitoxin system HicA family toxin Toxin
EL263_RS08615 1627580..1627759 - 180 WP_001809903.1 hypothetical protein -
EL263_RS08625 1627924..1628163 - 240 WP_000818078.1 hypothetical protein -
EL263_RS08635 1628433..1629704 + 1272 WP_054387466.1 replication-associated recombination protein A -
EL263_RS08645 1630249..1631568 - 1320 WP_000502560.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6396.53 Da        Isoelectric Point: 10.8214

>T32477 WP_172592534.1 NZ_AP018938:c1627437-1627264 [Streptococcus pneumoniae]
MTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHGELNKYTERGIGKQVGL

Download         Length: 174 bp

>T32477 NZ_AP018938:c1627437-1627264 [Streptococcus pneumoniae]
ATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCTCATATTAA
AATCGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAGGAAAGC
AAGTTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT32477 WP_000961810.1 NZ_AP018938:c1627227-1626775 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT32477 NZ_AP018938:c1627227-1626775 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References