Detailed information of TA system TA032476

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1132095..1132593
• Replicon: chromosome
• Accession: NZ_AP018938
• Organism: Streptococcus pneumoniae strain ATCC 49619

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EL263_RS05970
• Protein ID: WP_001812387.1
• Coordinates: 1132095..1132349 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: EL263_RS05975
• Protein ID: WP_000208080.1
• Coordinates: 1132351..1132593 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL263_RS05955	1127364..1129832	-	2469	WP_001152989.1	DNA gyrase subunit A	-
EL263_RS05960	1130026..1131012	+	987	WP_000204727.1	L-lactate dehydrogenase	-
EL263_RS05965	1131275..1132048	-	774	WP_044811410.1	ion transporter	-
EL263_RS05970	1132095..1132349	-	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EL263_RS05975	1132351..1132593	-	243	WP_000208080.1	hypothetical protein	Antitoxin
EL263_RS05980	1132684..1133493	-	810	WP_001289493.1	MBL fold metallo-hydrolase	-
EL263_RS05985	1133495..1134844	-	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
EL263_RS05990	1134837..1135541	-	705	WP_000722076.1	response regulator transcription factor	-
EL263_RS05995	1135596..1136771	-	1176	WP_000886125.1	A/G-specific adenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T32476 WP_001812387.1 NZ_AP018938:c1132349-1132095 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T32476 NZ_AP018938:c1132349-1132095 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAATCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT32476 WP_000208080.1 NZ_AP018938:c1132593-1132351 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT32476 NZ_AP018938:c1132593-1132351 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7