Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1706940..1707602 Replicon chromosome
Accession NZ_AP018936
Organism Streptococcus pneumoniae strain NU83127

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EL277_RS08960 Protein ID WP_000192221.1
Coordinates 1707429..1707602 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag EL277_RS08955 Protein ID WP_000961810.1
Coordinates 1706940..1707392 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL277_RS08930 1702830..1703573 - 744 WP_001188203.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
EL277_RS08935 1703575..1704525 - 951 WP_000451135.1 50S ribosomal protein L11 methyltransferase -
EL277_RS08940 1704663..1705091 - 429 WP_000401988.1 NUDIX hydrolase -
EL277_RS08945 1705093..1706160 - 1068 WP_061364929.1 M50 family metallopeptidase -
EL277_RS08950 1706179..1706649 - 471 WP_000257084.1 DUF3013 family protein -
EL277_RS08955 1706940..1707392 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EL277_RS08960 1707429..1707602 - 174 WP_000192221.1 type II toxin-antitoxin system HicA family toxin Toxin
EL277_RS08965 1707745..1707924 - 180 WP_001809903.1 hypothetical protein -
EL277_RS08975 1708089..1708328 - 240 WP_000818078.1 hypothetical protein -
EL277_RS08985 1708598..1709869 + 1272 WP_001113209.1 replication-associated recombination protein A -
EL277_RS08995 1710288..1711415 - 1128 WP_126443150.1 site-specific integrase -
EL277_RS09000 1711415..1711597 - 183 WP_061590400.1 DUF3173 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6368.47 Da        Isoelectric Point: 10.8214

>T32469 WP_000192221.1 NZ_AP018936:c1707602-1707429 [Streptococcus pneumoniae]
MTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHGELNKYTERGIGKQAGL

Download         Length: 174 bp

>T32469 NZ_AP018936:c1707602-1707429 [Streptococcus pneumoniae]
ATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCATATTAA
AATCGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAGGAAAGC
AAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT32469 WP_000961810.1 NZ_AP018936:c1707392-1706940 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT32469 NZ_AP018936:c1707392-1706940 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References