Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/-
Location 604723..605341 Replicon chromosome
Accession NZ_AP018936
Organism Streptococcus pneumoniae strain NU83127

Toxin (Protein)


Gene name relE Uniprot ID A0A4F7JJU4
Locus tag EL277_RS03190 Protein ID WP_000385025.1
Coordinates 604723..605091 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0I9CGM3
Locus tag EL277_RS03195 Protein ID WP_000105960.1
Coordinates 605081..605341 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL277_RS03155 600127..600597 + 471 WP_000335592.1 HIT family protein -
EL277_RS03160 600600..601316 + 717 WP_000747772.1 M15 family metallopeptidase -
EL277_RS11895 601356..601493 - 138 WP_001827247.1 hypothetical protein -
EL277_RS03165 601625..602050 + 426 WP_001085809.1 50S ribosomal protein L11 -
EL277_RS03170 602258..602947 + 690 WP_001085675.1 50S ribosomal protein L1 -
EL277_RS03175 603701..603781 - 81 Protein_588 UDP-galactopyranose mutase -
EL277_RS03180 603789..604151 + 363 WP_000895070.1 protein-export chaperone SecB -
EL277_RS03190 604723..605091 - 369 WP_000385025.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL277_RS03195 605081..605341 - 261 WP_000105960.1 hypothetical protein Antitoxin
EL277_RS03200 605666..606658 + 993 WP_001240812.1 ATP-binding cassette domain-containing protein -
EL277_RS03205 606660..607478 + 819 WP_000594189.1 ABC-2 family transporter protein -
EL277_RS03210 607480..608265 + 786 WP_000760712.1 ABC transporter permease -
EL277_RS03215 608304..608582 + 279 WP_001812029.1 hypothetical protein -
EL277_RS03220 608567..608764 + 198 WP_001812028.1 hypothetical protein -
EL277_RS11710 609145..609231 - 87 Protein_597 UDP-galactopyranose mutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 14633.92 Da        Isoelectric Point: 8.0387

>T32465 WP_000385025.1 NZ_AP018936:c605091-604723 [Streptococcus pneumoniae]
MDYKVRFTEQARQDLDDIFIYYSTEFSENIAKKVITRLQQITNLLIFSPEGGISFDHKIGYSLYPENMLRMIVSKQYLLF
YLIHEKEVHTLRIINSRTDYLNQLDHLFRTCRKLFSSQIISL

Download         Length: 369 bp

>T32465 NZ_AP018936:c605091-604723 [Streptococcus pneumoniae]
ATGGACTATAAAGTACGCTTCACAGAACAAGCCAGACAAGACTTAGACGATATCTTCATCTACTACTCCACAGAGTTCAG
TGAAAACATAGCCAAGAAAGTCATCACTCGTCTACAACAAATTACCAACCTACTCATCTTCTCACCAGAGGGCGGTATTA
GCTTTGATCATAAAATCGGATACTCCCTCTATCCAGAAAATATGCTCAGAATGATTGTCTCTAAACAATACCTGCTCTTT
TACCTCATTCATGAAAAAGAAGTCCATACCCTGAGAATTATCAACTCACGCACCGACTACCTAAACCAACTCGACCACCT
CTTTCGTACATGTAGGAAACTATTTTCCTCACAAATAATCTCATTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9809.13 Da        Isoelectric Point: 4.3322

>AT32465 WP_000105960.1 NZ_AP018936:c605341-605081 [Streptococcus pneumoniae]
MSTLTRDRVYNFCVNTQLFEEAKTILESKNISLSDALNLFVEQIVLEKGLTIKTADQPKAELDKGYQDIIEGRLYDADEV
FSKYGL

Download         Length: 261 bp

>AT32465 NZ_AP018936:c605341-605081 [Streptococcus pneumoniae]
ATGTCAACACTTACACGAGACCGAGTTTATAACTTCTGCGTCAATACTCAACTATTTGAAGAAGCAAAAACCATCCTAGA
AAGCAAAAACATCAGCCTTTCAGATGCCCTCAACCTCTTTGTAGAACAAATCGTCCTTGAAAAAGGTCTAACAATTAAAA
CAGCCGACCAACCCAAAGCAGAACTAGATAAAGGCTACCAAGATATCATCGAAGGGCGTCTCTACGACGCAGACGAGGTC
TTTTCAAAGTATGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4F7JJU4

Antitoxin

Source ID Structure
AlphaFold DB A0A0I9CGM3

References