Detailed information of TA system TA032462

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 239131..239743
• Replicon: chromosome
• Accession: NZ_AP018935
• Organism: Streptococcus agalactiae strain HU-GS5823

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q8E7D3
• Locus tag: EL269_RS01435
• Protein ID: WP_000384859.1
• Coordinates: 239131..239466 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: EL269_RS01440
• Protein ID: WP_000259017.1
• Coordinates: 239456..239743 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL269_RS01405	234329..234970	+	642	WP_000591145.1	hypothetical protein	-
EL269_RS01415	235270..236145	+	876	WP_000421240.1	hypothetical protein	-
EL269_RS01420	236181..236615	+	435	WP_001220479.1	hypothetical protein	-
EL269_RS01425	236932..238188	+	1257	WP_000122836.1	plasmid recombination protein	-
EL269_RS01430	238356..238826	+	471	WP_000130119.1	hypothetical protein	-
EL269_RS01435	239131..239466	-	336	WP_000384859.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EL269_RS01440	239456..239743	-	288	WP_000259017.1	hypothetical protein	Antitoxin
EL269_RS01445	240250..240540	+	291	WP_000078283.1	WXG100 family type VII secretion target	-
EL269_RS01450	240642..241049	+	408	WP_000749954.1	hypothetical protein	-
EL269_RS01455	241049..241609	+	561	WP_001865562.1	hypothetical protein	-
EL269_RS01460	241582..242262	+	681	WP_001865565.1	hypothetical protein	-
EL269_RS01465	242247..242633	+	387	WP_000259069.1	hypothetical protein	-
EL269_RS01470	242667..242948	+	282	WP_000052406.1	hypothetical protein	-
EL269_RS01490	243791..244651	+	861	WP_000477654.1	Rgg/GadR/MutR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	231161..240017	8856

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13296.98 Da
• Isoelectric Point: 4.6565

>T32462 WP_000384859.1 NZ_AP018935:c239466-239131 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T32462 NZ_AP018935:c239466-239131 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGGGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT32462 WP_000259017.1 NZ_AP018935:c239743-239456 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT32462 NZ_AP018935:c239743-239456 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6