Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 2273965..2274537 Replicon chromosome
Accession NZ_AP018930
Organism Sulfuracidifex tepidarius strain IC-007

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag F1551_RS11490 Protein ID WP_232048927.1
Coordinates 2274166..2274537 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag F1551_RS13850 Protein ID WP_232516017.1
Coordinates 2273965..2274108 (+) Length 48 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1551_RS11470 (IC007_2546) 2269409..2270974 - 1566 WP_162302145.1 cation:proton antiporter -
F1551_RS11475 (IC007_2547) 2271069..2271938 - 870 WP_149528808.1 DMT family transporter -
F1551_RS11480 (IC007_2548) 2272367..2273677 - 1311 WP_173569919.1 ATP-binding protein -
F1551_RS13850 (IC007_2550) 2273965..2274108 + 144 WP_232516017.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
F1551_RS11490 (IC007_2551) 2274166..2274537 + 372 WP_232048927.1 PIN domain-containing protein Toxin
F1551_RS11495 (IC007_2552) 2274624..2275619 - 996 WP_054845775.1 alcohol dehydrogenase catalytic domain-containing protein -
F1551_RS11500 (IC007_2553) 2275859..2276038 + 180 WP_054845776.1 hypothetical protein -
F1551_RS11505 (IC007_2554) 2276115..2276576 + 462 WP_054845777.1 tetratricopeptide repeat protein -
F1551_RS11510 (IC007_2555) 2276866..2277075 + 210 WP_149565055.1 hypothetical protein -
F1551_RS11515 (IC007_2557) 2277320..2277787 + 468 WP_162302146.1 dTDP-4-dehydrorhamnose 3,5-epimerase family protein -
F1551_RS11520 (IC007_2558) 2277796..2279016 + 1221 WP_149565057.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(10-113)

Antitoxin

SpoVT-AbrB domain

(6-45)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14382.62 Da        Isoelectric Point: 4.9711

>T32459 WP_232048927.1 NZ_AP018930:2274166-2274537 [Sulfuracidifex tepidarius]
MKPERMLEAIVDTNLIVAIIFRHHEKHCEALKEWKDIDKAYLPLVCVSEIAYFFIKNSLNLEILNEVLNDPKIEIVQNTN
EDVYYTLRNKEAVKGYDDFNDLLILSVAGRLNLRYLPLTESSR

Download         Length: 372 bp

>T32459 NZ_AP018930:2274166-2274537 [Sulfuracidifex tepidarius]
ATGAAGCCGGAGAGAATGTTGGAAGCAATAGTTGACACGAACTTAATAGTAGCGATTATTTTCAGACATCACGAAAAGCA
TTGTGAAGCTCTTAAGGAATGGAAAGACATAGATAAGGCATATTTACCCCTGGTATGTGTCTCGGAAATCGCTTATTTCT
TCATAAAGAACAGTCTTAATTTAGAAATATTAAATGAGGTCTTGAACGACCCAAAAATTGAGATAGTCCAAAACACTAAT
GAAGACGTATATTATACGCTACGTAATAAAGAAGCCGTAAAAGGTTACGACGATTTCAATGACCTTCTAATACTATCTGT
AGCTGGGAGACTGAACTTACGTTACTTACCTTTGACAGAAAGTTCAAGATGA

Antitoxin


Download         Length: 48 a.a.        Molecular weight: 5421.36 Da        Isoelectric Point: 8.5322

>AT32459 WP_232516017.1 NZ_AP018930:2273965-2274108 [Sulfuracidifex tepidarius]
MEEVEVTRNYQTAIPYEARRKLGIEVVDKLIVTVEGDKMIIQKKKGT

Download         Length: 144 bp

>AT32459 NZ_AP018930:2273965-2274108 [Sulfuracidifex tepidarius]
ATGGAAGAGGTTGAGGTGACAAGAAACTATCAAACCGCAATACCTTACGAAGCTAGACGAAAGCTCGGCATAGAGGTCGT
AGACAAGTTGATAGTGACAGTTGAGGGTGATAAGATGATAATTCAGAAGAAGAAGGGGACATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References