Detailed information of TA system TA032457

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/NGN_SP-AbrB
• Location: 566954..567545
• Replicon: chromosome
• Accession: NZ_AP018929
• Organism: Sulfuracidifex tepidarius strain IC-006

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: IC007_RS02610
• Protein ID: WP_232048982.1
• Coordinates: 567168..567545 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A510DT36
• Locus tag: IC007_RS02605
• Protein ID: WP_054846032.1
• Coordinates: 566954..567187 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IC007_RS02565 (IC006_0582)	561996..562508	+	513	WP_054846038.1	MFS transporter	-
IC007_RS02570 (IC006_0583)	562901..563269	+	369	WP_054846037.1	HEPN domain-containing protein	-
IC007_RS02575 (IC006_0584)	563301..563594	+	294	WP_232049038.1	nucleotidyltransferase domain-containing protein	-
IC007_RS02580 (IC006_0586)	564296..564538	+	243	WP_054846070.1	hypothetical protein	-
IC007_RS02585 (IC006_0587)	564528..564920	+	393	WP_054846035.1	type II toxin-antitoxin system VapC family toxin	-
IC007_RS02590	565015..565206	+	192	WP_149528309.1	hypothetical protein	-
IC007_RS02595 (IC006_0588)	565509..565922	-	414	WP_054846034.1	PIN domain-containing protein	-
IC007_RS02600 (IC006_0589)	565894..566142	-	249	WP_054846033.1	hypothetical protein	-
IC007_RS13645	566240..566359	+	120	Protein_546	IS5/IS1182 family transposase	-
IC007_RS02605 (IC006_0591)	566954..567187	+	234	WP_054846032.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
IC007_RS02610 (IC006_0592)	567168..567545	+	378	WP_232048982.1	type II toxin-antitoxin system VapC family toxin	Toxin
IC007_RS14020 (IC006_0594)	568004..568126	-	123	WP_269472355.1	hypothetical protein	-
IC007_RS02615 (IC006_0595)	568412..568591	+	180	WP_054846030.1	hypothetical protein	-
IC007_RS02620 (IC006_0596)	569154..569465	-	312	WP_256202595.1	type II toxin-antitoxin system VapC family toxin	-
IC007_RS13205	570561..570704	-	144	WP_156303766.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-116)

Antitoxin

• SpoVT-AbrB domain (5-43)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14208.60 Da
• Isoelectric Point: 9.6828

>T32457 WP_232048982.1 NZ_AP018929:567168-567545 [Sulfuracidifex tepidarius]
VRKVMLDASAIMLYFYGNEKLKEIIENSEVYVNSVNLTEFLYAYARAKGWKEGLFKYSIIRNSFKLIDVNKDDIITTSAK
LKIRYNLSLGDSFLLASAKHIKGVAVTSDHELKDVKEVKVLVVSL

Nucleotide

• Length: 378 bp

>T32457 NZ_AP018929:567168-567545 [Sulfuracidifex tepidarius]
GTGAGAAAAGTAATGCTTGACGCATCGGCAATTATGCTATATTTCTATGGGAATGAGAAACTGAAGGAGATAATAGAAAA
TAGTGAAGTTTACGTTAATTCTGTAAATCTCACAGAGTTCCTTTATGCTTACGCCAGAGCTAAAGGATGGAAAGAAGGAC
TATTCAAATACAGTATCATAAGAAACTCCTTTAAACTGATTGATGTAAATAAAGATGATATAATTACTACTTCTGCTAAG
TTGAAAATTAGGTATAACCTTTCTCTGGGGGACTCTTTCCTTTTAGCATCAGCTAAACATATTAAAGGAGTTGCAGTAAC
TAGCGACCATGAGCTCAAGGACGTAAAAGAGGTAAAAGTTCTAGTAGTTTCTTTGTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 9026.47 Da
• Isoelectric Point: 9.4248

>AT32457 WP_054846032.1 NZ_AP018929:566954-567187 [Sulfuracidifex tepidarius]
MYRLKVHKKGITVIPKEIRDKFNIKEGDEVNVIVDDKGIYIFPMQTIEKYFGSDKGAIDALKILEEERRKEREKSNA

Nucleotide

• Length: 234 bp

>AT32457 NZ_AP018929:566954-567187 [Sulfuracidifex tepidarius]
ATGTATAGGTTAAAAGTTCATAAAAAGGGGATTACGGTAATACCCAAAGAGATTAGAGATAAGTTCAACATAAAAGAGGG
TGACGAGGTAAACGTTATAGTCGACGATAAAGGTATTTATATATTTCCTATGCAGACTATTGAAAAATATTTCGGAAGCG
ATAAAGGTGCTATAGATGCTCTAAAAATTTTAGAGGAAGAGAGGAGAAAAGAACGTGAGAAAAGTAATGCTTGA

Structures

Antitoxin

• AlphaFold DB: A0A510DT36