Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1606727..1607515 Replicon chromosome
Accession NZ_AP018923
Organism Staphylococcus aureus strain JMUB3031

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag D5070_RS08155 Protein ID WP_000525004.1
Coordinates 1607054..1607515 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag D5070_RS08150 Protein ID WP_000333630.1
Coordinates 1606727..1607041 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D5070_RS08090 1601869..1603035 - 1167 WP_064129389.1 DUF2800 domain-containing protein -
D5070_RS08095 1603032..1603394 - 363 WP_000985976.1 hypothetical protein -
D5070_RS08100 1603409..1603732 - 324 WP_000174994.1 hypothetical protein -
D5070_RS08105 1603811..1603972 - 162 WP_001285963.1 DUF1270 family protein -
D5070_RS08110 1603985..1604248 - 264 WP_001124159.1 helix-turn-helix domain-containing protein -
D5070_RS08115 1604273..1604488 - 216 WP_001097552.1 hypothetical protein -
D5070_RS08120 1604543..1604908 + 366 WP_001128433.1 hypothetical protein -
D5070_RS08125 1604877..1605122 - 246 WP_001025401.1 DUF2829 domain-containing protein -
D5070_RS08130 1605178..1605387 + 210 WP_000642492.1 hypothetical protein -
D5070_RS08135 1605377..1605520 - 144 WP_000939498.1 hypothetical protein -
D5070_RS08140 1605549..1606325 - 777 WP_001148544.1 Rha family transcriptional regulator -
D5070_RS08145 1606339..1606575 - 237 WP_001121027.1 helix-turn-helix domain-containing protein -
D5070_RS08150 1606727..1607041 + 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
D5070_RS08155 1607054..1607515 + 462 WP_000525004.1 hypothetical protein Toxin
D5070_RS08160 1607533..1608117 + 585 WP_000825948.1 hypothetical protein -
D5070_RS08165 1608347..1608493 + 147 WP_072433242.1 hypothetical protein -
D5070_RS08170 1608490..1609104 - 615 WP_000191466.1 hypothetical protein -
D5070_RS08175 1609230..1610435 + 1206 WP_000264747.1 site-specific integrase -
D5070_RS08180 1610478..1612505 - 2028 WP_117219080.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1564908..1629793 64885


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T32441 WP_000525004.1 NZ_AP018923:1607054-1607515 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T32441 NZ_AP018923:1607054-1607515 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT32441 WP_000333630.1 NZ_AP018923:1606727-1607041 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT32441 NZ_AP018923:1606727-1607041 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References