Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 850619..851096 Replicon chromosome
Accession NZ_AP018923
Organism Staphylococcus aureus strain JMUB3031

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag D5070_RS04250 Protein ID WP_000052076.1
Coordinates 850619..850807 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag D5070_RS04255 Protein ID WP_001059690.1
Coordinates 850836..851096 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D5070_RS04220 846609..847130 + 522 WP_000824464.1 hypothetical protein -
D5070_RS04225 847471..848157 + 687 WP_117218907.1 thermonuclease family protein -
D5070_RS04230 848514..848714 + 201 WP_001059082.1 cold-shock protein -
D5070_RS04235 849210..849428 - 219 WP_000005886.1 hypothetical protein -
D5070_RS04240 849490..849774 - 285 WP_001004401.1 hypothetical protein -
D5070_RS04245 849862..850431 - 570 WP_001106654.1 hypothetical protein -
D5070_RS04250 850619..850807 - 189 WP_000052076.1 hypothetical protein Toxin
D5070_RS04255 850836..851096 - 261 WP_001059690.1 hypothetical protein Antitoxin
D5070_RS04260 851436..851639 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
D5070_RS04265 851636..851872 - 237 WP_000368687.1 hypothetical protein -
D5070_RS04270 852096..852677 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
D5070_RS04275 852750..853367 - 618 WP_000255544.1 LysE/ArgO family amino acid transporter -
D5070_RS04280 853522..854016 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
D5070_RS04285 854415..854837 - 423 WP_000974464.1 organic hydroperoxide resistance protein -
D5070_RS04290 854985..855701 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T32437 WP_000052076.1 NZ_AP018923:c850807-850619 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T32437 NZ_AP018923:c850807-850619 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT32437 WP_001059690.1 NZ_AP018923:c851096-850836 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT32437 NZ_AP018923:c851096-850836 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References