Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 838460..838937 Replicon chromosome
Accession NZ_AP018922
Organism Staphylococcus aureus strain JMUB1273

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag JMUB1273_RS04190 Protein ID WP_000052076.1
Coordinates 838460..838648 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag JMUB1273_RS04195 Protein ID WP_001059690.1
Coordinates 838677..838937 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMUB1273_RS04160 834495..834965 + 471 WP_000824472.1 hypothetical protein -
JMUB1273_RS04165 835306..835992 + 687 WP_001566557.1 thermonuclease family protein -
JMUB1273_RS04170 836349..836549 + 201 WP_001059082.1 cold-shock protein -
JMUB1273_RS04175 837044..837269 - 226 Protein_769 hypothetical protein -
JMUB1273_RS04180 837331..837615 - 285 WP_001004394.1 hypothetical protein -
JMUB1273_RS04185 837703..838272 - 570 WP_001106652.1 hypothetical protein -
JMUB1273_RS04190 838460..838648 - 189 WP_000052076.1 hypothetical protein Toxin
JMUB1273_RS04195 838677..838937 - 261 WP_001059690.1 hypothetical protein Antitoxin
JMUB1273_RS04200 839278..839481 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
JMUB1273_RS04205 839478..839714 - 237 WP_000368687.1 hypothetical protein -
JMUB1273_RS04210 839939..840520 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
JMUB1273_RS04215 840593..841210 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
JMUB1273_RS04220 841365..841859 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
JMUB1273_RS04225 842258..842680 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
JMUB1273_RS04230 842828..843544 + 717 WP_000150019.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T32420 WP_000052076.1 NZ_AP018922:c838648-838460 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T32420 NZ_AP018922:c838648-838460 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT32420 WP_001059690.1 NZ_AP018922:c838937-838677 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT32420 NZ_AP018922:c838937-838677 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References