Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 77684..78411 Replicon plasmid pPA12743CP
Accession NZ_AP018921
Organism Pseudonocardia autotrophica strain NBRC 12743

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag Pdca_RS34140 Protein ID WP_085916760.1
Coordinates 78016..78411 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag Pdca_RS34135 Protein ID WP_085916761.1
Coordinates 77684..77926 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Pdca_RS34110 73230..73502 + 273 WP_085916769.1 DUF1490 family protein -
Pdca_RS34115 73526..75748 + 2223 WP_125911714.1 cation-translocating P-type ATPase -
Pdca_RS34120 75956..76078 - 123 WP_085916765.1 type B 50S ribosomal protein L36 -
Pdca_RS34125 76075..76569 - 495 WP_085916764.1 DUF305 domain-containing protein -
Pdca_RS34130 76731..76973 + 243 WP_085916763.1 hypothetical protein -
Pdca_RS34135 77684..77926 + 243 WP_085916761.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
Pdca_RS34140 78016..78411 + 396 WP_085916760.1 type II toxin-antitoxin system VapC family toxin Toxin
Pdca_RS34145 79116..79757 - 642 WP_085916768.1 zf-HC2 domain-containing protein -
Pdca_RS34150 79738..80096 - 359 Protein_70 hypothetical protein -
Pdca_RS34155 80606..81124 - 519 WP_158092381.1 methyltransferase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..289155 289155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Post-segregation antitoxin CcdA

(3-46)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 13732.84 Da        Isoelectric Point: 5.5783

>T32419 WP_085916760.1 NZ_AP018921:78016-78411 [Pseudonocardia autotrophica]
MVVVDASVVVDLLAGTELAAAVARRLSGTVLHAPAHCEAEVLSALGRLQRAGELTVDEVDAAVAAVAAMPLTRHPLAALL
PGAWARRGRLRLLDALYVELASQLDTVVVTTDHRLARATDRAEAIVAADDR

Download         Length: 396 bp

>T32419 NZ_AP018921:78016-78411 [Pseudonocardia autotrophica]
ATGGTGGTGGTCGATGCTTCGGTGGTGGTGGATCTGCTGGCCGGTACCGAGCTGGCCGCCGCTGTCGCGCGGCGGCTGTC
GGGCACCGTGCTACACGCCCCGGCGCACTGTGAGGCCGAAGTGCTCTCGGCGCTTGGCCGGCTCCAGCGCGCCGGTGAGC
TGACCGTTGACGAGGTGGACGCGGCAGTGGCCGCGGTGGCCGCGATGCCGCTCACGCGCCACCCGTTGGCCGCCTTGCTG
CCCGGGGCGTGGGCCCGGCGCGGGCGTCTGCGTCTGCTGGACGCACTCTATGTGGAGTTGGCCAGCCAACTCGACACAGT
GGTCGTGACTACCGATCACCGCTTGGCCCGTGCCACCGACCGCGCTGAGGCCATCGTCGCCGCCGACGATCGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8630.66 Da        Isoelectric Point: 4.5184

>AT32419 WP_085916761.1 NZ_AP018921:77684-77926 [Pseudonocardia autotrophica]
MARLNVWVPDELAARARAQSLNVSALTQQALAAELDRQATDTWLAELPAPRRPVAHATVVAALDAARAEFEADPEQGARE

Download         Length: 243 bp

>AT32419 NZ_AP018921:77684-77926 [Pseudonocardia autotrophica]
ATGGCTCGGTTGAATGTGTGGGTTCCGGACGAGTTGGCCGCTCGGGCACGGGCACAGTCGTTGAATGTGTCGGCGTTGAC
CCAGCAGGCCTTGGCCGCCGAGCTCGACCGGCAGGCCACCGACACGTGGCTGGCCGAGTTGCCGGCACCGCGGCGACCGG
TCGCCCACGCGACGGTGGTGGCCGCGCTCGACGCCGCCCGCGCCGAGTTCGAGGCCGATCCCGAGCAGGGGGCTCGCGAG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References