Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2124890..2125515 Replicon chromosome
Accession NZ_AP018827
Organism Asticcacaulis excentricus strain M6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EM6_RS09830 Protein ID WP_126422361.1
Coordinates 2125111..2125515 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EM6_RS09825 Protein ID WP_126422359.1
Coordinates 2124890..2125111 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EM6_RS09810 2120841..2121344 - 504 WP_126422353.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
EM6_RS09815 2121355..2122557 - 1203 WP_126422355.1 threonine ammonia-lyase -
EM6_RS09820 2122799..2124838 + 2040 WP_126422357.1 NAD(+) synthase -
EM6_RS09825 2124890..2125111 + 222 WP_126422359.1 antitoxin Antitoxin
EM6_RS09830 2125111..2125515 + 405 WP_126422361.1 tRNA(fMet)-specific endonuclease VapC Toxin
EM6_RS09835 2125512..2126132 - 621 WP_126422363.1 carbonic anhydrase -
EM6_RS09840 2126205..2126408 - 204 WP_126422365.1 hypothetical protein -
EM6_RS09845 2126407..2127471 + 1065 WP_126422367.1 NUDIX domain-containing protein -
EM6_RS09850 2127555..2128157 + 603 WP_126422369.1 thymidine kinase -
EM6_RS09855 2128162..2129145 + 984 WP_126422371.1 serine/threonine dehydratase -
EM6_RS09860 2129234..2130001 + 768 WP_126422373.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14879.14 Da        Isoelectric Point: 7.2160

>T32409 WP_126422361.1 NZ_AP018827:2125111-2125515 [Asticcacaulis excentricus]
MLRYMLDTNLCIRVLRDRPAALRERFNAEAAGMCLSTIVLNELLYGAAKSARPLDHRQAVENFASRLDVLPFDAVAADHA
ADIRAVLERQGRMIGGYDVLIAGHARSRGLIVVTGNLGEFRRVDGLRCEDWLAD

Download         Length: 405 bp

>T32409 NZ_AP018827:2125111-2125515 [Asticcacaulis excentricus]
ATGCTGCGTTATATGCTCGATACCAATCTGTGTATCCGCGTGCTGCGTGATCGACCCGCGGCCTTGCGCGAGCGTTTCAA
TGCCGAAGCCGCGGGCATGTGTCTCTCGACCATCGTTCTGAACGAGCTTTTGTATGGGGCGGCGAAATCTGCCCGTCCGC
TGGACCATCGTCAGGCGGTGGAAAATTTCGCCAGCCGCCTCGACGTTCTGCCGTTTGATGCCGTTGCCGCTGATCATGCC
GCAGATATCCGTGCGGTTCTGGAACGGCAGGGGCGCATGATCGGCGGGTATGATGTGCTGATCGCCGGTCACGCCCGCAG
TCGCGGCCTGATCGTGGTCACGGGCAATCTGGGTGAGTTTCGCCGGGTTGACGGACTGCGCTGTGAAGACTGGCTCGCGG
ATTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8377.49 Da        Isoelectric Point: 6.2936

>AT32409 WP_126422359.1 NZ_AP018827:2124890-2125111 [Asticcacaulis excentricus]
MTQTTLFQSNRTQAVRLPKDVAFPEGVREVTILREGQRRIIVPANAVWDDFFAAKGIELSEREQPSLQTRESF

Download         Length: 222 bp

>AT32409 NZ_AP018827:2124890-2125111 [Asticcacaulis excentricus]
ATGACCCAGACCACGCTGTTCCAGTCCAACCGCACACAGGCCGTCCGTTTGCCGAAGGATGTCGCCTTTCCGGAGGGCGT
TCGCGAAGTCACCATCCTGCGTGAAGGCCAGCGTCGGATTATCGTACCCGCCAATGCCGTCTGGGACGATTTCTTTGCGG
CGAAAGGCATAGAGTTGTCGGAACGCGAGCAGCCATCGCTTCAAACGCGCGAAAGCTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References