Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 1521631..1522213 Replicon chromosome
Accession NZ_AP018827
Organism Asticcacaulis excentricus strain M6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EM6_RS07060 Protein ID WP_126421388.1
Coordinates 1521833..1522213 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EM6_RS07055 Protein ID WP_126421386.1
Coordinates 1521631..1521825 (+) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EM6_RS07035 1516986..1517921 - 936 WP_126421378.1 TraB/GumN family protein -
EM6_RS07040 1517962..1518177 - 216 WP_126421380.1 helix-turn-helix transcriptional regulator -
EM6_RS07045 1518180..1518653 - 474 WP_172961155.1 DUF2975 domain-containing protein -
EM6_RS07050 1519142..1521565 + 2424 WP_126421384.1 glucan 1,4-alpha-glucosidase -
EM6_RS07055 1521631..1521825 + 195 WP_126421386.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
EM6_RS07060 1521833..1522213 + 381 WP_126421388.1 PIN domain-containing protein Toxin
EM6_RS07065 1522276..1523775 - 1500 WP_126421389.1 Do family serine endopeptidase -
EM6_RS07070 1524000..1524512 - 513 WP_126421391.1 cytochrome c-type biogenesis protein CcmH -
EM6_RS07075 1524509..1526491 - 1983 WP_126421393.1 heme lyase CcmF/NrfE family subunit -
EM6_RS07080 1526488..1526982 - 495 WP_126421395.1 cytochrome c maturation protein CcmE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-114)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14138.44 Da        Isoelectric Point: 5.1082

>T32407 WP_126421388.1 NZ_AP018827:1521833-1522213 [Asticcacaulis excentricus]
MNVLVDTSVWVDHFRNDNADLTALLLRDEVMMHPMIITELSCGHVPAPRAETLNAMRLLRTSPQASLNEISDFIEREKLF
GLGCGLVDFALLASALLTPYAQLWTLDKRLNALAERFGIGYLPVRQ

Download         Length: 381 bp

>T32407 NZ_AP018827:1521833-1522213 [Asticcacaulis excentricus]
ATGAACGTGCTGGTCGATACCTCGGTCTGGGTGGATCATTTTCGCAACGACAATGCGGATTTGACGGCGCTTCTGCTGCG
GGATGAGGTGATGATGCATCCCATGATCATTACGGAACTGAGTTGCGGACACGTACCGGCACCGCGCGCAGAGACCCTGA
ATGCTATGCGCCTGCTGCGCACCAGTCCTCAGGCAAGCCTCAATGAGATTTCCGACTTTATTGAACGCGAAAAACTGTTC
GGTCTGGGCTGCGGGCTGGTCGATTTTGCCTTGCTGGCCTCGGCCTTGCTCACGCCCTACGCACAGCTATGGACACTGGA
CAAACGCCTGAATGCTCTGGCTGAGCGTTTTGGCATAGGCTACTTACCCGTGCGGCAATAA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7105.16 Da        Isoelectric Point: 6.2549

>AT32407 WP_126421386.1 NZ_AP018827:1521631-1521825 [Asticcacaulis excentricus]
MRTTVTIDDALFEQAVQLADPGMDRADIFREAMKTFVRIQAARRLAALGGAAPDMTGIPRRRED

Download         Length: 195 bp

>AT32407 NZ_AP018827:1521631-1521825 [Asticcacaulis excentricus]
ATGCGCACCACCGTGACCATTGATGACGCCCTGTTTGAACAGGCGGTGCAACTGGCCGATCCCGGTATGGATCGCGCTGA
TATTTTCCGCGAAGCCATGAAAACCTTCGTACGGATTCAGGCCGCCCGACGTCTGGCGGCCCTGGGGGGGGCGGCCCCCG
ACATGACCGGTATTCCGCGCCGTCGCGAAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References