Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2682193..2683861 Replicon chromosome
Accession NZ_AP018823
Organism Aquitalea magnusonii strain H3

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag DLM_RS12735 Protein ID WP_089086020.1
Coordinates 2682533..2683861 (+) Length 443 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag DLM_RS12730 Protein ID WP_197715399.1
Coordinates 2682193..2682453 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLM_RS12710 2678515..2678805 + 291 WP_089086025.1 nucleotidyltransferase family protein -
DLM_RS12715 2678973..2679662 + 690 WP_145985850.1 hypothetical protein -
DLM_RS12720 2679688..2680203 + 516 WP_089086023.1 toll/interleukin-1 receptor domain-containing protein -
DLM_RS23090 2680314..2680514 + 201 WP_145985851.1 hypothetical protein -
DLM_RS12725 2681168..2681845 + 678 WP_089086022.1 hypothetical protein -
DLM_RS12730 2682193..2682453 + 261 WP_197715399.1 helix-turn-helix domain-containing protein Antitoxin
DLM_RS12735 2682533..2683861 + 1329 WP_089086020.1 type II toxin-antitoxin system HipA family toxin Toxin
DLM_RS12740 2683934..2684557 - 624 WP_089086019.1 DUF4166 domain-containing protein -
DLM_RS12745 2684554..2685033 - 480 WP_089086018.1 DUF2269 domain-containing protein -
DLM_RS12750 2685030..2685884 - 855 WP_089086017.1 NAD-dependent epimerase/dehydratase family protein -
DLM_RS12755 2685881..2686246 - 366 WP_089086016.1 hypothetical protein -
DLM_RS12760 2686364..2687260 - 897 WP_197715400.1 helix-turn-helix domain-containing protein -
DLM_RS12765 2687482..2688315 - 834 WP_089086014.1 SDR family NAD(P)-dependent oxidoreductase -
DLM_RS12770 2688479..2688712 + 234 WP_089086346.1 exodeoxyribonuclease VII small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2678802..2687389 8587


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-120)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-71)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 49040.00 Da        Isoelectric Point: 7.8111

>T32405 WP_089086020.1 NZ_AP018823:2682533-2683861 [Aquitalea magnusonii]
MVMRYEDLLSVKYQGDLVGALAFDRGRGLGHFEYDPAFRRKGIELSPLHMPLAAQVYQFPQLDPATFRGLPGMLADALPD
DFGNAVLNAWVAREGRAVSSITPLERLKYTGSRGMGALEFYPARQMKGLNASTNVAIDSLVEVAQEVLNQRAALQVNLAA
GVAERDAMLSLLSVGSSAGGARPKVVLAFDEGFRHARSGQTDAPAGFTHCLLKFDGVVEQQSGLETFGDPLGFGAMEYTY
YQMARQCGIVMEPCWLLDEGPRRHFVTRRFDRRGNRKLHVQTLCGLAHASYKQLGQYSYEEILQLMRRLGLGADDAAQLF
RRMVFNVVARNHDDHTKNFAFLLDPDSHAWQLAPAYDIAYSYKPGSHWVNSHATTINGKRDGFCRADFHAFSKLSKLFTP
AWIDGVIAQTVDVLAQWPVLARRNAVPDSIIGMVTPNLRLDI

Download         Length: 1329 bp

>T32405 NZ_AP018823:2682533-2683861 [Aquitalea magnusonii]
ATGGTGATGCGCTACGAGGATCTGCTGAGTGTGAAATACCAGGGCGATCTGGTGGGCGCTCTGGCTTTTGACAGGGGGCG
CGGGCTGGGCCATTTCGAATATGACCCGGCTTTCCGGCGCAAGGGCATTGAGCTGTCGCCCCTGCACATGCCGCTGGCAG
CGCAGGTTTATCAGTTTCCGCAGTTGGATCCGGCCACGTTCAGGGGCTTGCCCGGCATGTTGGCCGATGCCTTGCCGGAT
GATTTTGGCAATGCCGTGCTCAATGCCTGGGTGGCGCGTGAAGGCAGGGCGGTATCGAGTATCACGCCGCTTGAGCGGTT
GAAATACACCGGTTCACGCGGCATGGGGGCGCTGGAGTTTTATCCTGCGCGGCAGATGAAGGGGCTGAATGCCTCCACCA
ATGTGGCGATCGACAGTCTGGTAGAGGTGGCGCAGGAGGTGTTGAATCAGCGCGCTGCCTTGCAGGTGAATCTGGCCGCG
GGCGTGGCCGAGCGGGATGCCATGCTGAGCTTGCTGTCGGTGGGTAGCAGCGCAGGCGGCGCACGGCCCAAGGTGGTTTT
GGCGTTTGATGAGGGTTTTCGTCACGCCCGCTCTGGCCAGACAGATGCGCCGGCAGGTTTTACCCATTGCCTGCTGAAGT
TTGACGGTGTGGTGGAGCAGCAGTCCGGCCTGGAGACATTTGGTGACCCGCTGGGCTTTGGCGCAATGGAGTATACGTAT
TATCAGATGGCCCGCCAGTGCGGCATTGTCATGGAGCCTTGCTGGCTGCTGGACGAAGGGCCGCGCCGCCATTTTGTCAC
CCGCCGTTTTGACCGGCGCGGCAATCGCAAGCTGCATGTACAGACCTTGTGCGGCCTGGCGCATGCCAGTTACAAGCAGC
TGGGCCAGTATTCGTATGAGGAAATCTTGCAGTTGATGCGTCGCCTGGGGCTGGGGGCGGATGACGCTGCGCAATTGTTC
CGTCGCATGGTGTTCAATGTGGTGGCCAGAAACCACGACGACCACACCAAGAACTTTGCTTTTTTGCTGGACCCAGACAG
CCACGCCTGGCAGTTGGCCCCGGCCTACGATATTGCCTACAGCTACAAGCCCGGCAGTCACTGGGTAAACAGTCATGCCA
CCACCATCAATGGCAAGCGCGATGGCTTTTGCCGTGCCGATTTCCATGCTTTTAGCAAGCTGAGCAAGCTGTTCACCCCG
GCCTGGATAGATGGGGTGATTGCACAGACGGTGGACGTGCTGGCGCAATGGCCGGTGTTGGCCCGCCGCAATGCGGTGCC
GGATAGCATTATCGGTATGGTGACGCCCAATCTGCGGCTGGATATCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9280.54 Da        Isoelectric Point: 7.1047

>AT32405 WP_197715399.1 NZ_AP018823:2682193-2682453 [Aquitalea magnusonii]
MNHYDTSKSASALAEELGRRLRQARLEANISQDALASRAGLSRRAVQYAEAGKSQLDTFLALLLALGLDSQLDNLLPPGH
CLPCNC

Download         Length: 261 bp

>AT32405 NZ_AP018823:2682193-2682453 [Aquitalea magnusonii]
ATGAATCATTACGACACATCAAAAAGCGCCAGCGCCCTTGCCGAAGAACTGGGGCGTCGGCTACGCCAGGCCCGGCTGGA
GGCCAATATCTCGCAGGATGCATTGGCCAGCCGCGCCGGGCTGTCCCGCCGCGCGGTGCAATACGCCGAAGCGGGCAAGT
CCCAACTGGATACCTTTTTGGCGCTGTTGCTGGCGCTGGGGCTGGACAGCCAGTTGGACAATCTGCTGCCCCCCGGCCAT
TGTCTCCCCTGCAATTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References