Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 26391..26925 Replicon plasmid pBAR2
Accession NZ_AP018820
Organism Sphingomonas bisphenolicum strain AO1

Toxin (Protein)


Gene name relE Uniprot ID W1S6F4
Locus tag SBA_RS23160 Protein ID WP_004212931.1
Coordinates 26644..26925 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J8A6F9
Locus tag SBA_RS23155 Protein ID WP_011950390.1
Coordinates 26391..26657 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SBA_RS23135 (SBA_pBAR2_200) 22866..23732 + 867 WP_006953933.1 recombinase family protein -
SBA_RS23140 (SBA_pBAR2_210) 24296..24610 - 315 WP_011950393.1 hypothetical protein -
SBA_RS23145 (SBA_pBAR2_220) 24607..25260 - 654 WP_011950392.1 ParA family partition ATPase -
SBA_RS23150 (SBA_pBAR2_230) 25343..25972 - 630 WP_011950391.1 transcription elongation protein SprT -
SBA_RS23155 (SBA_pBAR2_240) 26391..26657 + 267 WP_011950390.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
SBA_RS23160 (SBA_pBAR2_250) 26644..26925 + 282 WP_004212931.1 type II toxin-antitoxin system YafQ family toxin Toxin
SBA_RS23165 (SBA_pBAR2_260) 26935..27555 + 621 WP_019086510.1 histidine phosphatase family protein -
SBA_RS23170 (SBA_pBAR2_270) 27552..28514 - 963 WP_041380120.1 tyrosine-type recombinase/integrase -
SBA_RS23175 (SBA_pBAR2_280) 28511..28906 - 396 WP_041380118.1 CopG family transcriptional regulator -
SBA_RS23180 (SBA_pBAR2_290) 28944..29315 - 372 WP_225900037.1 hypothetical protein -
SBA_RS23185 (SBA_pBAR2_300) 29562..29930 + 369 WP_158305177.1 hypothetical protein -
SBA_RS23190 (SBA_pBAR2_310) 29988..31019 + 1032 Protein_31 TolC family protein -
SBA_RS23195 (SBA_pBAR2_320) 31050..31610 - 561 WP_011950653.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..66398 66398


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10634.98 Da        Isoelectric Point: 8.0689

>T32404 WP_004212931.1 NZ_AP018820:26644-26925 [Sphingomonas bisphenolicum]
VRTIDRSTRFKRDYKRESKGRHRATLDADLLPVLAALATDTPLDPKYRDHDLSGDWAGYRDCHVKPDLVLIYAKPDDETL
RLARLGSHSEVFG

Download         Length: 282 bp

>T32404 NZ_AP018820:26644-26925 [Sphingomonas bisphenolicum]
GTGCGGACGATTGATCGTTCGACCCGGTTCAAGCGCGACTACAAGCGGGAATCAAAGGGCCGGCATCGAGCGACCCTCGA
TGCCGATCTTCTGCCTGTCCTGGCCGCGCTCGCGACCGACACGCCGCTTGATCCCAAATACCGCGACCATGATCTGAGCG
GCGATTGGGCGGGCTACCGCGATTGCCACGTCAAGCCCGATCTGGTGCTGATCTACGCCAAGCCCGACGACGAAACGCTG
CGCCTCGCGCGCCTTGGCTCGCATAGCGAGGTATTCGGATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9467.92 Da        Isoelectric Point: 6.3194

>AT32404 WP_011950390.1 NZ_AP018820:26391-26657 [Sphingomonas bisphenolicum]
MAVSDTYVRARIDNTTKERATAALGAMGLSISDAIRLLMLRIADERRLPFEVKVPNAATREAMAELAAGKGTKFASVDAL
MADLRADD

Download         Length: 267 bp

>AT32404 NZ_AP018820:26391-26657 [Sphingomonas bisphenolicum]
ATGGCTGTTTCCGACACCTATGTCCGCGCCAGGATCGACAATACGACGAAGGAACGCGCCACCGCCGCGCTGGGCGCGAT
GGGCCTTTCGATCTCCGACGCTATCCGACTGTTGATGCTGCGTATCGCCGACGAACGGCGCTTGCCTTTCGAGGTCAAGG
TTCCGAACGCCGCGACACGCGAGGCAATGGCAGAGCTGGCGGCGGGGAAGGGGACCAAGTTCGCCAGCGTCGATGCGCTG
ATGGCGGACCTCCGTGCGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W1S6F4

Antitoxin

Source ID Structure
AlphaFold DB A0A0J8A6F9

References