Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-parD/RHH(antitoxin)
Location 799081..799562 Replicon chromosome
Accession NZ_AP018818
Organism Sphingomonas bisphenolicum strain AO1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag SBA_RS22035 Protein ID WP_261937030.1
Coordinates 799081..799278 (-) Length 66 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag SBA_RS22040 Protein ID WP_261937031.1
Coordinates 799275..799562 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SBA_RS22015 (SBA_ch2_6980) 795368..795673 + 306 WP_224550883.1 (2Fe-2S)-binding protein -
SBA_RS22020 (SBA_ch2_6990) 795655..797028 + 1374 WP_261937028.1 NAD(P)/FAD-dependent oxidoreductase -
SBA_RS22025 (SBA_ch2_7000) 797025..798158 + 1134 WP_261937029.1 FAD-binding oxidoreductase -
SBA_RS22035 (SBA_ch2_7030) 799081..799278 - 198 WP_261937030.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SBA_RS22040 (SBA_ch2_7040) 799275..799562 - 288 WP_261937031.1 antitoxin of toxin-antitoxin stability system Antitoxin
SBA_RS22045 (SBA_ch2_7050) 799628..801100 - 1473 WP_261937032.1 aldehyde dehydrogenase family protein -
SBA_RS22050 (SBA_ch2_7060) 801305..802177 + 873 WP_224550888.1 GNAT family N-acetyltransferase -
SBA_RS22055 (SBA_ch2_7070) 802174..803637 + 1464 WP_261937033.1 NAD-dependent succinate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 798292..798678 386


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-61)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7326.44 Da        Isoelectric Point: 11.5530

>T32402 WP_261937030.1 NZ_AP018818:c799278-799081 [Sphingomonas bisphenolicum]
MRLRWTADAVRDRDAIYDYVEARSPRAAIRLDTIFSQKAADLSRLPAMGRPGRVPGTRELRAVGI

Download         Length: 198 bp

>T32402 NZ_AP018818:c799278-799081 [Sphingomonas bisphenolicum]
ATGAGGCTGCGCTGGACGGCCGATGCCGTCAGGGATCGTGACGCCATTTACGACTATGTCGAAGCGCGCAGCCCGCGCGC
GGCGATCAGGCTCGACACGATCTTTTCGCAAAAAGCAGCCGACCTGTCCCGGCTCCCTGCCATGGGCCGGCCTGGCCGGG
TGCCGGGAACGCGCGAACTAAGGGCTGTGGGGATTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10772.92 Da        Isoelectric Point: 7.2064

>AT32402 WP_261937031.1 NZ_AP018818:c799562-799275 [Sphingomonas bisphenolicum]
MNEATFTFRVDQELKGRFARAAKAQDRTGAQLLRDFMRDVVLREEQAESHDAWFRRQVDAGRASAQAGYLIAGDEVETHF
AARRAATLRTSDGER

Download         Length: 288 bp

>AT32402 NZ_AP018818:c799562-799275 [Sphingomonas bisphenolicum]
ATGAATGAGGCGACCTTCACCTTTCGCGTGGATCAGGAACTCAAGGGCCGCTTCGCCCGCGCGGCCAAGGCGCAGGATCG
CACCGGCGCGCAATTGTTGCGCGATTTCATGCGCGATGTCGTACTGCGCGAGGAACAGGCCGAAAGCCATGACGCCTGGT
TCCGTCGTCAGGTCGACGCCGGACGCGCATCCGCGCAGGCAGGCTACCTGATCGCCGGCGATGAAGTCGAGACGCATTTC
GCCGCACGACGTGCCGCCACGCTGCGGACATCAGACGGCGAGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References