Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2773986..2774821 Replicon chromosome
Accession NZ_AP018808
Organism Escherichia coli strain E2865

Toxin (Protein)


Gene name yeeV Uniprot ID A0A136X5A2
Locus tag EL389_RS14955 Protein ID WP_000854757.1
Coordinates 2774444..2774821 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag EL389_RS14950 Protein ID WP_001295723.1
Coordinates 2773986..2774354 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL389_RS14905 2770093..2770440 - 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
EL389_RS14910 2770437..2770841 - 405 WP_000839179.1 IS66 family insertion sequence hypothetical protein -
EL389_RS14915 2770930..2771271 + 342 WP_072097794.1 hypothetical protein -
EL389_RS14920 2771350..2771583 + 234 WP_001119729.1 DUF905 family protein -
EL389_RS14930 2771683..2772501 + 819 WP_001234620.1 DUF945 domain-containing protein -
EL389_RS14935 2772556..2773041 + 486 WP_000849582.1 antirestriction protein -
EL389_RS14940 2773057..2773533 + 477 WP_001186725.1 RadC family protein -
EL389_RS14945 2773602..2773823 + 222 WP_000692323.1 DUF987 domain-containing protein -
EL389_RS14950 2773986..2774354 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EL389_RS14955 2774444..2774821 + 378 WP_000854757.1 TA system toxin CbtA family protein Toxin
EL389_RS14960 2774818..2775021 + 204 WP_000761705.1 hypothetical protein -
EL389_RS14965 2775034..2775147 + 114 WP_001161660.1 DUF957 domain-containing protein -
EL389_RS14970 2775306..2776334 + 1029 Protein_2851 IS110 family transposase -
EL389_RS14980 2776788..2776970 + 183 WP_024167529.1 ethanolamine utilization protein -
EL389_RS14985 2777071..2777400 - 330 WP_000450409.1 DUF496 family protein -
EL389_RS14990 2777572..2778630 - 1059 WP_001200887.1 FUSC family protein -
EL389_RS14995 2778828..2779301 - 474 WP_001105384.1 DNA gyrase inhibitor SbmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14153.18 Da        Isoelectric Point: 7.3249

>T32383 WP_000854757.1 NZ_AP018808:2774444-2774821 [Escherichia coli]
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T32383 NZ_AP018808:2774444-2774821 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AAGCTGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT32383 WP_001295723.1 NZ_AP018808:2773986-2774354 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT32383 NZ_AP018808:2773986-2774354 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A136X5A2

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References