Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1383508..1384303 Replicon chromosome
Accession NZ_AP018808
Organism Escherichia coli strain E2865

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag EL389_RS07170 Protein ID WP_000854914.1
Coordinates 1383929..1384303 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9LM11
Locus tag EL389_RS07165 Protein ID WP_001280953.1
Coordinates 1383508..1383882 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL389_RS07130 1378863..1379768 + 906 WP_000203541.1 chemotaxis protein -
EL389_RS07135 1379765..1380835 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
EL389_RS07145 1381175..1381993 + 819 WP_001234682.1 DUF945 domain-containing protein -
EL389_RS07150 1382084..1382569 + 486 WP_000214398.1 antirestriction protein -
EL389_RS07155 1382585..1383061 + 477 WP_001186738.1 RadC family protein -
EL389_RS07160 1383124..1383345 + 222 WP_000692323.1 DUF987 domain-containing protein -
EL389_RS07165 1383508..1383882 + 375 WP_001280953.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EL389_RS07170 1383929..1384303 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
EL389_RS07175 1384300..1384791 + 492 WP_126347097.1 hypothetical protein -
EL389_RS07180 1384803..1385000 + 198 WP_000839282.1 DUF957 domain-containing protein -
EL389_RS07185 1385085..1385927 + 843 WP_001280481.1 DUF4942 domain-containing protein -
EL389_RS07195 1386398..1387336 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
EL389_RS07200 1387391..1388128 + 738 WP_000283664.1 zinc-binding phosphatase -
EL389_RS07205 1388152..1388706 + 555 WP_001001902.1 molecular chaperone YcdY -
EL389_RS07210 1388808..1389299 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 1371767..1394863 23096


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T32364 WP_000854914.1 NZ_AP018808:1383929-1384303 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T32364 NZ_AP018808:1383929-1384303 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13734.56 Da        Isoelectric Point: 6.6249

>AT32364 WP_001280953.1 NZ_AP018808:1383508-1383882 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPALATTS

Download         Length: 375 bp

>AT32364 NZ_AP018808:1383508-1383882 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACTCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LM11

References