Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1176681..1177159 Replicon chromosome
Accession NZ_AP018808
Organism Escherichia coli strain E2865

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag EL389_RS05775 Protein ID WP_001303876.1
Coordinates 1176681..1176968 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag EL389_RS05780 Protein ID WP_000536233.1
Coordinates 1176968..1177159 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL389_RS05745 1171911..1174361 - 2451 WP_000048583.1 exonuclease -
EL389_RS05750 1174455..1174646 - 192 WP_001098307.1 DUF1482 family protein -
EL389_RS05755 1174643..1174831 - 189 WP_000413705.1 cell division inhibition protein DicB -
EL389_RS05760 1175399..1175608 + 210 WP_001133037.1 hypothetical protein -
EL389_RS05765 1175609..1176247 - 639 WP_000394543.1 hypothetical protein -
EL389_RS05770 1176259..1176411 - 153 WP_000380316.1 DUF1391 family protein -
EL389_RS05775 1176681..1176968 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL389_RS05780 1176968..1177159 - 192 WP_000536233.1 hypothetical protein Antitoxin
EL389_RS05785 1177187..1177588 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
EL389_RS05790 1177697..1177969 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
EL389_RS05795 1177953..1178378 + 426 WP_000693855.1 Rha family transcriptional regulator -
EL389_RS05800 1178585..1179040 - 456 WP_000273724.1 hypothetical protein -
EL389_RS05805 1179119..1180234 + 1116 WP_001205821.1 hypothetical protein -
EL389_RS05810 1180241..1180987 + 747 WP_000788742.1 ATP-binding protein -
EL389_RS05815 1181009..1181779 + 771 WP_000451007.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T32363 WP_001303876.1 NZ_AP018808:c1176968-1176681 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T32363 NZ_AP018808:c1176968-1176681 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT32363 WP_000536233.1 NZ_AP018808:c1177159-1176968 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT32363 NZ_AP018808:c1177159-1176968 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References