Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 52424..52946 | Replicon | plasmid pE2863-4 |
| Accession | NZ_AP018806 | ||
| Organism | Escherichia coli strain E2863 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | U9YLU1 |
| Locus tag | EL381_RS29485 | Protein ID | WP_000638823.1 |
| Coordinates | 52424..52705 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U9Y7J1 |
| Locus tag | EL381_RS29490 | Protein ID | WP_000121741.1 |
| Coordinates | 52695..52946 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EL381_RS29450 | 48573..48893 | - | 321 | WP_000362080.1 | VirB3 family type IV secretion system protein | - |
| EL381_RS29455 | 48964..49152 | - | 189 | WP_050567133.1 | hypothetical protein | - |
| EL381_RS29460 | 49254..49838 | - | 585 | WP_001177113.1 | lytic transglycosylase domain-containing protein | - |
| EL381_RS29465 | 49859..50257 | - | 399 | WP_001153665.1 | hypothetical protein | - |
| EL381_RS29470 | 50376..50813 | - | 438 | WP_000539665.1 | type IV pilus biogenesis protein PilM | - |
| EL381_RS29475 | 50819..52054 | - | 1236 | WP_015059538.1 | TcpQ domain-containing protein | - |
| EL381_RS29480 | 52057..52356 | - | 300 | WP_000835764.1 | IncN plasmid KikA protein | - |
| EL381_RS29485 | 52424..52705 | - | 282 | WP_000638823.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| EL381_RS29490 | 52695..52946 | - | 252 | WP_000121741.1 | hypothetical protein | Antitoxin |
| EL381_RS29495 | 53046..53681 | - | 636 | WP_015059536.1 | hypothetical protein | - |
| EL381_RS29500 | 53754..54041 | - | 288 | WP_001032611.1 | EexN family lipoprotein | - |
| EL381_RS29505 | 54054..54308 | - | 255 | WP_001043555.1 | EexN family lipoprotein | - |
| EL381_RS29510 | 54310..54951 | - | 642 | WP_001425343.1 | conjugal transfer protein TrbJ | - |
| EL381_RS29515 | 54957..55952 | - | 996 | WP_001028543.1 | type IV secretion system protein | - |
| EL381_RS29520 | 55956..56213 | - | 258 | WP_000739144.1 | hypothetical protein | - |
| EL381_RS29525 | 56210..56512 | - | 303 | WP_001360345.1 | hypothetical protein | - |
| EL381_RS29530 | 56493..56750 | - | 258 | WP_001542015.1 | hypothetical protein | - |
| EL381_RS29535 | 56783..57229 | - | 447 | WP_001243165.1 | hypothetical protein | - |
| EL381_RS30070 | 57240..57410 | - | 171 | WP_000550720.1 | hypothetical protein | - |
| EL381_RS29540 | 57414..57857 | - | 444 | WP_000964330.1 | NfeD family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..60684 | 60684 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10945.79 Da Isoelectric Point: 10.4997
>T32358 WP_000638823.1 NZ_AP018806:c52705-52424 [Escherichia coli]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
Download Length: 282 bp
>T32358 NZ_AP018806:c52705-52424 [Escherichia coli]
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9223.38 Da Isoelectric Point: 3.9823
>AT32358 WP_000121741.1 NZ_AP018806:c52946-52695 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
Download Length: 252 bp
>AT32358 NZ_AP018806:c52946-52695 [Escherichia coli]
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|