Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-DUF971
Location 2612996..2613591 Replicon chromosome
Accession NZ_AP018795
Organism Acidithiobacillus ferridurans strain JCM 18981

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag AFERRID_RS13485 Protein ID WP_126605735.1
Coordinates 2612996..2613292 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag AFERRID_RS13490 Protein ID WP_126605470.1
Coordinates 2613295..2613591 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AFERRID_RS13440 2608335..2608742 - 408 WP_126605462.1 hypothetical protein -
AFERRID_RS15335 2608961..2609089 + 129 WP_197722445.1 BrnT family toxin -
AFERRID_RS13450 2609193..2609513 + 321 WP_126605463.1 BrnA antitoxin family protein -
AFERRID_RS13455 2609522..2610112 - 591 WP_126605464.1 S26 family signal peptidase -
AFERRID_RS13460 2610114..2610605 - 492 WP_126605465.1 hypothetical protein -
AFERRID_RS13465 2610630..2610845 - 216 WP_126605466.1 hypothetical protein -
AFERRID_RS13470 2611012..2611275 - 264 WP_126605467.1 hypothetical protein -
AFERRID_RS13480 2611595..2612821 - 1227 WP_126605469.1 conjugal transfer protein TraB -
AFERRID_RS13485 2612996..2613292 + 297 WP_126605735.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AFERRID_RS13490 2613295..2613591 + 297 WP_126605470.1 putative addiction module antidote protein Antitoxin
AFERRID_RS13495 2614155..2614838 - 684 WP_126605471.1 hypothetical protein -
AFERRID_RS13500 2615184..2615474 - 291 WP_126605472.1 hypothetical protein -
AFERRID_RS13505 2615471..2617519 - 2049 WP_126605473.1 DNA topoisomerase 3 -
AFERRID_RS13510 2617686..2618117 + 432 WP_126605474.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2590114..2631127 41013


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(11-93)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11141.94 Da        Isoelectric Point: 10.0301

>T32280 WP_126605735.1 NZ_AP018795:2612996-2613292 [Acidithiobacillus ferridurans]
MVEIKQTETFRKWWMKLKDERARGIVAGRLDRLAYGLIGDAEPVGEGVSELRIHYGPGYRVYFQQRGSMIIVLLCGGNKS
TQAKDIKVAKRLAAEWSE

Download         Length: 297 bp

>T32280 NZ_AP018795:2612996-2613292 [Acidithiobacillus ferridurans]
ATGGTTGAGATCAAGCAGACAGAGACCTTCAGAAAATGGTGGATGAAGCTCAAAGATGAACGAGCTCGCGGTATCGTGGC
CGGTCGTCTGGATCGGCTCGCTTACGGCTTGATCGGCGACGCGGAGCCAGTGGGGGAGGGGGTAAGTGAGTTACGCATCC
ACTATGGCCCTGGATACCGTGTTTATTTTCAGCAACGGGGGAGCATGATCATCGTCTTGCTCTGCGGTGGCAACAAGAGC
ACGCAAGCGAAGGACATCAAGGTGGCGAAGCGCCTGGCTGCTGAATGGAGTGAATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10225.61 Da        Isoelectric Point: 5.8085

>AT32280 WP_126605470.1 NZ_AP018795:2613295-2613591 [Acidithiobacillus ferridurans]
MSEKLSTFDPAEGLTSDAAIAAFMADAFESADAGYIAHALGVVARAKGMAQIAGETGLSREQLYRSFSERGNPTLKTTLA
VMKVLGIELTAKTGSQGR

Download         Length: 297 bp

>AT32280 NZ_AP018795:2613295-2613591 [Acidithiobacillus ferridurans]
ATGAGTGAAAAATTGTCTACTTTTGACCCTGCCGAAGGGCTGACATCAGACGCGGCCATCGCAGCCTTCATGGCCGATGC
GTTTGAATCTGCAGACGCCGGCTACATTGCGCACGCGCTGGGCGTCGTGGCCCGCGCCAAGGGAATGGCTCAGATCGCTG
GGGAAACTGGTCTTTCTCGTGAACAGTTGTACCGCTCATTCAGCGAGCGCGGCAATCCGACGCTCAAGACCACGCTGGCA
GTCATGAAGGTCCTGGGGATTGAACTTACGGCAAAAACGGGTTCACAGGGCCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References