Detailed information of TA system TA032277

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 1516476..1517140
• Replicon: chromosome
• Accession: NZ_AP018795
• Organism: Acidithiobacillus ferridurans strain JCM 18981

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: AFERRID_RS07850
• Protein ID: WP_113527578.1
• Coordinates: 1516778..1517140 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: AFERRID_RS07845
• Protein ID: WP_113527577.1
• Coordinates: 1516476..1516781 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AFERRID_RS07835	1513058..1515805	-	2748	WP_172959355.1	quinoprotein amine dehydrogenase, beta chain-like protein	-
AFERRID_RS07840	1515940..1516146	-	207	Protein_1520	TonB-dependent receptor	-
AFERRID_RS07845	1516476..1516781	-	306	WP_113527577.1	helix-turn-helix domain-containing protein	Antitoxin
AFERRID_RS07850	1516778..1517140	-	363	WP_113527578.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AFERRID_RS07855	1517188..1517481	-	294	Protein_1523	SAM-dependent DNA methyltransferase	-
AFERRID_RS07860	1517642..1518319	-	678	WP_126604796.1	DUF541 domain-containing protein	-
AFERRID_RS07865	1518525..1519397	-	873	WP_126604797.1	pirin family protein	-
AFERRID_RS07870	1519401..1519598	-	198	WP_113527582.1	hypothetical protein	-
AFERRID_RS07875	1519922..1521019	+	1098	WP_126604799.1	ADP-ribosylglycohydrolase family protein	-
AFERRID_RS07880	1520989..1521903	-	915	WP_126604801.1	magnesium transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (29-84)

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13770.91 Da
• Isoelectric Point: 9.9763

>T32277 WP_113527578.1 NZ_AP018795:c1517140-1516778 [Acidithiobacillus ferridurans]
MVQSQRPLFWVASAKKDLMDMPEDVRDTFGYALHLAQIGGKHAQAKPLKGFGSADLVEIVEDFKGDTFRAVYTVRFQEKI
YVLHSFQKKATQGIRTPKPDMDKIHERLKWAERHAKGVIE

Nucleotide

• Length: 363 bp

>T32277 NZ_AP018795:c1517140-1516778 [Acidithiobacillus ferridurans]
ATGGTTCAATCGCAACGTCCTTTATTCTGGGTGGCCTCCGCCAAAAAAGATCTCATGGATATGCCCGAGGATGTGCGGGA
TACCTTTGGGTATGCGCTGCATCTGGCGCAAATCGGCGGCAAACATGCCCAAGCCAAACCGTTAAAAGGCTTTGGCTCGG
CGGATCTGGTTGAGATCGTCGAAGATTTCAAGGGGGACACGTTTCGAGCGGTGTATACGGTGCGCTTTCAAGAGAAAATT
TACGTTCTGCACAGCTTTCAGAAGAAAGCGACGCAGGGCATCCGCACACCCAAACCCGATATGGACAAGATACATGAACG
GTTGAAATGGGCAGAGCGACACGCCAAGGGGGTGATCGAATGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 10824.62 Da
• Isoelectric Point: 5.0349

>AT32277 WP_113527577.1 NZ_AP018795:c1516781-1516476 [Acidithiobacillus ferridurans]
MNIEMSSGNVYADIGAPDAEEMLLKAQLASRIADMIQSKGFTQSQAAELLGIPQPKLSLMLRGQFRGISEAKMLECLARL
GRDIQIVIGPEHAGTGNIVVV

Nucleotide

• Length: 306 bp

>AT32277 NZ_AP018795:c1516781-1516476 [Acidithiobacillus ferridurans]
ATGAACATCGAGATGAGTAGTGGCAATGTCTATGCGGACATCGGTGCGCCGGATGCAGAGGAAATGCTTTTGAAGGCACA
ACTGGCATCCCGTATTGCGGACATGATCCAGAGCAAAGGATTTACGCAATCGCAGGCAGCGGAACTGCTGGGTATCCCAC
AACCCAAGCTGTCCCTGATGCTGCGGGGGCAATTCCGGGGAATCAGTGAAGCCAAAATGCTGGAATGCCTGGCCCGGCTG
GGCCGGGATATTCAGATCGTCATCGGACCGGAACATGCAGGGACCGGGAATATTGTGGTGGTGTGA