Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 911587..912167 Replicon chromosome
Accession NZ_AP018795
Organism Acidithiobacillus ferridurans strain JCM 18981

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag AFERRID_RS04600 Protein ID WP_126604462.1
Coordinates 911841..912167 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag AFERRID_RS04595 Protein ID WP_126604461.1
Coordinates 911587..911844 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AFERRID_RS04580 907971..909485 + 1515 WP_126604458.1 hypothetical protein -
AFERRID_RS04585 909596..910618 + 1023 WP_126604459.1 GDP-mannose 4,6-dehydratase -
AFERRID_RS04590 910635..911474 + 840 WP_126604460.1 methyltransferase domain-containing protein -
AFERRID_RS04595 911587..911844 + 258 WP_126604461.1 antitoxin Antitoxin
AFERRID_RS04600 911841..912167 + 327 WP_126604462.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AFERRID_RS15145 912175..912315 + 141 WP_172959336.1 hypothetical protein -
AFERRID_RS04605 912396..912626 - 231 WP_126604463.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
AFERRID_RS04610 912630..912767 - 138 WP_197722480.1 hypothetical protein -
AFERRID_RS04615 912802..913182 - 381 WP_126604464.1 SCP2 sterol-binding domain-containing protein -
AFERRID_RS04620 913319..913615 + 297 WP_126605675.1 DUF1778 domain-containing protein -
AFERRID_RS04625 913616..914134 + 519 WP_126604465.1 GNAT family N-acetyltransferase -
AFERRID_RS04630 914286..914882 + 597 WP_192796491.1 ATP-binding cassette domain-containing protein -
AFERRID_RS04635 914882..915643 + 762 WP_126604467.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 902248..941655 39407


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-107)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11713.64 Da        Isoelectric Point: 8.0184

>T32273 WP_126604462.1 NZ_AP018795:911841-912167 [Acidithiobacillus ferridurans]
MKRGDIYLVSLDPTAGHEQSGSRPVLIVSPAEFNETTKLPVILPITNGGEFARRLGFAVPVTGIKTTGVVRCDQPRVMDL
AARNARKVDTLPVPIMDEVLARVATIFE

Download         Length: 327 bp

>T32273 NZ_AP018795:911841-912167 [Acidithiobacillus ferridurans]
ATGAAGCGAGGTGACATCTACCTCGTGTCGCTCGATCCCACCGCCGGGCATGAACAAAGCGGTAGCCGTCCTGTCCTGAT
CGTGTCGCCTGCGGAGTTTAATGAAACCACCAAGCTGCCGGTGATCCTACCGATCACCAATGGTGGTGAGTTCGCCCGTC
GCCTTGGTTTCGCGGTGCCCGTGACCGGCATAAAGACCACCGGCGTCGTGCGCTGCGACCAGCCGCGCGTGATGGACTTG
GCCGCCCGAAATGCCCGCAAGGTGGACACTCTGCCGGTACCGATCATGGACGAGGTGCTGGCCAGGGTCGCCACGATCTT
CGAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9123.55 Da        Isoelectric Point: 5.5255

>AT32273 WP_126604461.1 NZ_AP018795:911587-911844 [Acidithiobacillus ferridurans]
MHTTKLRKVGGSIMLAVPPAFLEQLHLQAGATVGLVVDHGLLVVNPSPRPRYTLAELLAASDYSQPQPVEEREWVDAPAV
GGELL

Download         Length: 258 bp

>AT32273 NZ_AP018795:911587-911844 [Acidithiobacillus ferridurans]
ATGCACACAACCAAACTGCGCAAGGTCGGCGGCTCGATCATGTTGGCCGTCCCACCCGCATTCCTTGAACAGCTGCACCT
GCAAGCCGGTGCGACGGTCGGCTTGGTCGTCGATCATGGTCTACTGGTGGTCAATCCCAGTCCACGCCCGCGCTACACAC
TTGCAGAGTTGCTGGCCGCGTCCGACTATTCCCAGCCGCAACCGGTCGAGGAGCGCGAATGGGTCGATGCGCCCGCCGTG
GGCGGTGAGCTGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References