Detailed information of TA system TA032271

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 164824..165331
• Replicon: chromosome
• Accession: NZ_AP018795
• Organism: Acidithiobacillus ferridurans strain JCM 18981

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: AFERRID_RS00790
• Protein ID: WP_126604175.1
• Coordinates: 164824..165084 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: AFERRID_RS00795
• Protein ID: WP_126605650.1
• Coordinates: 165077..165331 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AFERRID_RS00765	160682..162433	-	1752	WP_126604171.1	hypothetical protein	-
AFERRID_RS15240	162531..162833	-	303	WP_197722465.1	hypothetical protein	-
AFERRID_RS00775	162941..163675	+	735	WP_126604172.1	LexA family transcriptional regulator	-
AFERRID_RS00780	163763..163969	+	207	WP_126604173.1	hypothetical protein	-
AFERRID_RS00785	164533..164793	+	261	WP_126604174.1	pyocin activator PrtN family protein	-
AFERRID_RS00790	164824..165084	-	261	WP_126604175.1	Txe/YoeB family addiction module toxin	Toxin
AFERRID_RS00795	165077..165331	-	255	WP_126605650.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
AFERRID_RS00800	165870..167144	+	1275	WP_172959307.1	MFS transporter	-
AFERRID_RS00805	167215..169620	-	2406	WP_126604177.1	DNA topoisomerase IV subunit A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	30740..196039	165299

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10411.84 Da
• Isoelectric Point: 9.0210

>T32271 WP_126604175.1 NZ_AP018795:c165084-164824 [Acidithiobacillus ferridurans]
MPERISWTLAAWEDYEYWQGQDRKTLRRVNALIRDCLRNPHSGIGKPEPLRENLSGYWSRRIDDVNRLVYRTTTIDLIII
SCRYHY

Nucleotide

• Length: 261 bp

>T32271 NZ_AP018795:c165084-164824 [Acidithiobacillus ferridurans]
ATGCCTGAGCGCATCTCCTGGACGCTGGCCGCCTGGGAAGATTATGAATACTGGCAAGGGCAGGATCGGAAAACACTCCG
AAGAGTGAATGCGCTGATACGAGATTGCCTGCGGAACCCGCACTCGGGCATTGGTAAGCCAGAGCCACTGCGGGAAAACC
TCTCAGGATACTGGTCCCGGCGTATTGACGACGTTAACCGGCTGGTTTATCGCACCACGACTATAGATCTGATTATTATT
TCCTGCCGGTACCATTATTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9047.12 Da
• Isoelectric Point: 4.9432

>AT32271 WP_126605650.1 NZ_AP018795:c165331-165077 [Acidithiobacillus ferridurans]
MHVVSYSEARDNLKAVMDRAVEDADVTIITRRGSSNAVLLSQDLFDSLMETVHLLRSPANAAHLVQSIAQDQAGQTSPRG
LADA

Nucleotide

• Length: 255 bp

>AT32271 NZ_AP018795:c165331-165077 [Acidithiobacillus ferridurans]
ATGCACGTTGTGAGTTATTCGGAAGCCCGTGACAATCTGAAGGCGGTAATGGACAGAGCCGTTGAAGATGCCGATGTTAC
CATCATTACGAGGCGTGGATCGTCTAACGCGGTTTTGCTTTCGCAGGATCTTTTTGACAGCCTGATGGAAACGGTTCACC
TGCTGCGCTCGCCGGCCAATGCTGCACACCTGGTGCAATCCATAGCACAAGATCAGGCAGGGCAAACATCTCCCCGTGGA
CTGGCTGATGCCTGA