Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 499356..500191 | Replicon | chromosome |
| Accession | NZ_AP018784 | ||
| Organism | Escherichia coli strain SK1144 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PMM7 |
| Locus tag | DAECLI1_RS02300 | Protein ID | WP_000854720.1 |
| Coordinates | 499356..499733 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1P8X0 |
| Locus tag | DAECLI1_RS02305 | Protein ID | WP_001539669.1 |
| Coordinates | 499823..500191 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DAECLI1_RS02270 | 494624..496162 | - | 1539 | WP_001187191.1 | lysine decarboxylation/transport transcriptional activator CadC | - |
| DAECLI1_RS02275 | 497045..497371 | - | 327 | WP_000779482.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| DAECLI1_RS02280 | 497368..497631 | - | 264 | WP_001143297.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| DAECLI1_RS02285 | 497703..498569 | - | 867 | WP_001290180.1 | DUF4942 domain-containing protein | - |
| DAECLI1_RS02290 | 498662..498859 | - | 198 | WP_000839238.1 | DUF957 domain-containing protein | - |
| DAECLI1_RS02295 | 498871..499359 | - | 489 | WP_021535504.1 | hypothetical protein | - |
| DAECLI1_RS02300 | 499356..499733 | - | 378 | WP_000854720.1 | TA system toxin CbtA family protein | Toxin |
| DAECLI1_RS02305 | 499823..500191 | - | 369 | WP_001539669.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| DAECLI1_RS02310 | 500271..500492 | - | 222 | WP_000692349.1 | DUF987 domain-containing protein | - |
| DAECLI1_RS02315 | 500579..501055 | - | 477 | WP_001186788.1 | RadC family protein | - |
| DAECLI1_RS02320 | 501071..501556 | - | 486 | WP_000849596.1 | antirestriction protein | - |
| DAECLI1_RS02325 | 501611..502429 | - | 819 | WP_001234642.1 | DUF945 domain-containing protein | - |
| DAECLI1_RS02335 | 502529..502762 | - | 234 | WP_001119719.1 | DUF905 family protein | - |
| DAECLI1_RS02340 | 502848..503252 | + | 405 | WP_001539664.1 | IS66 family insertion sequence hypothetical protein | - |
| DAECLI1_RS02345 | 503249..503596 | + | 348 | WP_000612617.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| DAECLI1_RS02350 | 503645..505183 | + | 1539 | WP_061186101.1 | IS66 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14089.02 Da Isoelectric Point: 7.9087
>T32238 WP_000854720.1 NZ_AP018784:c499733-499356 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ
Download Length: 378 bp
>T32238 NZ_AP018784:c499733-499356 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13614.39 Da Isoelectric Point: 5.9550
>AT32238 WP_001539669.1 NZ_AP018784:c500191-499823 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSN
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSN
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT32238 NZ_AP018784:c500191-499823 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCATGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAAT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCATGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAAT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829FW05 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829FYK7 |